Evidence map›Paper›PMID 31382259›Full record

Observational studyBlood purification2020

Acute Kidney Injury in Critically Ill Children: A Retrospective Analysis of Risk Factors.

Francesca De Zan, Angela Amigoni, Roberta Pozzato, Andrea Pettenazzo, Luisa Murer, Enrico Vidal

Abstract readObservational Study
PubMed Publisher
In one paragraph

Observational study in Blood purification, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
1.8field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Francesca De ZanNephrology, Dialysis and Transplant Unit, Department of Woman's and Child's Health, University Hospital of Padova, Padova, Italy.
Angela AmigoniPediatric Intensive Care Unit, Department of Woman's and Child's Health, University Hospital of Padova, Padova, Italy.
Roberta PozzatoPediatric Intensive Care Unit, Department of Woman's and Child's Health, University Hospital of Padova, Padova, Italy.
Andrea PettenazzoPediatric Intensive Care Unit, Department of Woman's and Child's Health, University Hospital of Padova, Padova, Italy.
Luisa MurerNephrology, Dialysis and Transplant Unit, Department of Woman's and Child's Health, University Hospital of Padova, Padova, Italy.
Enrico VidalDivision of Pediatrics, Department of Medicine, University of Udine, Udine, Italy, enrico.vidal@inwind.it.
University of Padua · ITUniversity of Udine · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionChildren admitted to paediatric intensive care unit (PICU) are at risk of acute kidney injury (AKI). However, few paediatric studies have focused on the identification of factors potentially associated with the development of this condition. The aim of our study was to assess the incidence rate of AKI, identify risk factors, and evaluate clinical outcome in a large sample of critically ill children.

methodsThis retrospective observational study was conducted including patients admitted to our PICU from January 2014 to December 2016. AKI was defined according to Kidney Disease: Improving Global Outcome criteria.

resultsA total of 222 PICU patients out of 811 (27%) had AKI (stage I 39%, stage II 24%, stage III 37%). The most common PICU admission diagnoses in AKI cases were heart disease (38.6%), respiratory failure (16.8%) and postsurgical non-cardiac patients (11%). Hypoxic-ischaemic was the most frequent cause of AKI. Significant risk factors for AKI following multivariate analysis were age >2 months (OR 2.43; 95% CI 1.03-7.87; p = 0.05), serum creatinine at admission >44 µmol/L (OR 2.23; 95% CI 1.26-3.94; p = 0.006), presence of comorbidities (OR 1.84; 95% CI 1.03-3.30; p = 0.04), use of inotropes (OR 2.56; 95% CI 1.23-5.35; p= 0.012) and diuretics (OR 2.78; 95% CI 1.49-5.19; p = 0.001), exposure to nephrotoxic drugs (OR 1.66; 95% CI 1.01-2.91; p= 0.04), multiple organ dysfunction syndrome (OR 2.68; 95% CI 1.43-5.01; p = 0.002), and coagulopathy (OR 1.89; 95% CI 1.05-3.38, p = 0.03). AKI was associated with a significant longer PICU stay (median LOS of 8 days, interquartile range [IQR] 3-16, versus 4 days, IQR 2-8, in non-AKI patients; p < 0.001). The mortality rate resulted tenfold higher in AKI than non-AKI patients (12.6 vs. 1.2%; p < 0.001).

conclusionsThe incidence of AKI in critically ill children is high, with an associated increased length of stay and risk of mortality. In the PICU setting, risk factors of AKI are multiple and mainly associated with illness severity.

Indexed as

Acute Kidney InjuryHospital MortalityIntensive Care Units, PediatricChildChild, PreschoolCritical IllnessDisease-Free SurvivalFemaleHumansIncidenceInfantInfant, NewbornMaleRetrospective StudiesRisk FactorsSurvival RateAcute kidney injuryCritically ill childrenKidney Disease: Improving Global OutcomeOutcomePediatric intensive care unit

Identifiers

PMID31382259
OpenAlexW2966483303

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.