ArticlePloS one2019
Uric acid variability at midlife as an independent predictor of coronary heart disease and all-cause mortality.
Article in PloS one, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Uric Acid Variability Is Associated with Poor Prognosis in Heart Failure.Journal of clinical medicine · 2026Article
- Serum uric acid variability and short-term mortality in chronic kidney disease: a retrospective cohort study with independent replication in MIMIC-IV.Frontiers in nutrition · 2026Article
- A Review on Optical Biosensors for Monitoring of Uric Acid and Blood Glucose Using Portable POCT Devices: Status, Challenges, and Future Horizons.Biosensors · 2025Review
- Association between annual changes and visit-to-visit variability of serum uric acid and the kidney outcome in a general population.Renal failure · 2024Article
- Non-Interventional Weight Changes Are Associated with Alterations in Serum Uric Acid Levels.Journal of clinical medicine · 2024Article
- Serum uric acid and outcome in hospitalized elderly patients with chronic heart failure through the whole spectrum of ejection fraction phenotypes.BMC cardiovascular disorders · 2023Article
- Article
- Change in Serum Uric Acid is a Useful Predictor of All-Cause Mortality among Community-Dwelling Persons.International journal of analytical chemistry · 2023Article
- Application of machine learning algorithms to construct and validate a prediction model for coronary heart disease risk in patients with periodontitis: a population-based study.Frontiers in cardiovascular medicine · 2023Article
- Evaluation of the prognostic ability of serum uric acid for elderly acute coronary syndrome patients with diabetes mellitus: a prospective cohort study.Journal of Zhejiang University. Science. B · 2021Article
- Variability of risk factors and diabetes complications.Cardiovascular diabetology · 2021Review
- Serum uric acid and risk of stroke: a dose-response meta-analysis.Journal of clinical biochemistry and nutrition · 2021Article
- Visit-to-visit variability of serum uric acid measurements and the risk of all-cause mortality in the general population.Arthritis research & therapy · 2021Article
- Relationship Between Change in Serum Uric Acid and Ischemic Stroke in Chinese Hypertensive Patients.Frontiers in cardiovascular medicine · 2021Article
- Uric Acid Variability and All-Cause Mortality: A Prospective Cohort Study in Northern China.The journal of nutrition, health & aging · 2021Article
- Uric Acid Variability as a Predictive Marker of Newly Developed Cardiovascular Events in Type 2 Diabetes.Frontiers in cardiovascular medicine · 2021Article
- Uric acid preconditioning alleviated doxorubicin induced JNK activation and Cx43 phosphorylation associated cardiotoxicity via activation of AMPK-SHP2 signaling pathway.Annals of translational medicine · 2020Article
- Selected Atherosclerosis-Related Diseases May Differentially Affect the Relationship between Plasma Advanced Glycation End Products, Receptor sRAGE, and Uric Acid.Journal of clinical medicine · 2020Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSerum uric acid (SUA) has long been associated with cardiovascular disease. Variability of serum uric acid (SUA) has seldom been examined in association with long-term morbidity and mortality. Therefore, we aimed to investigate the association between SUA variability and long-term all-cause and specific-cause mortality.
methodsAmong 10,059 men, aged 40-65, tenured civil servants and municipal employees in Israel, 8822 participants who were examined in 1963, 1965 and 1968 had assessment of diabetic and coronary morbidity status and SUA levels. We conducted analysis examining whether the standard deviations (SD) of Z-scores of SUA across study visits predicted coronary heart disease (CHD) and mortality. Hazard ratios (HR) associated with the SD of SUA-Z were calculated for stroke, CHD mortality and all-cause mortality associated with quartiles of the above variability.
resultsMultivariate analysis of 18-year CHD mortality yielded a significant association with the 1963-1968 SD of SUA-Z with age adjusted HR of CHD mortality of 0.97 (95% CI, 0.8-1.19), 1.05 (95% CI, 0.87-1.28) and 1.37 (95% CI, 1.15-1.65) for quartiles 2 to 4 respectively). The results of all-cause mortality similarly and strongly indicated increasing age-adjusted mortality risk with increasing SD of SUA-Z: HR = 1.08 (95% CI, 0.97-1.21), 1.15 (1.03-1.28) and 1.37 (1.23-1.51). No association was observed between the SD of SUA-Z and stroke mortality.
conclusionIn this cohort of tenured male workers, with diverse occupations, higher variability of SUA measurement taken over 5 years was clearly predictive of 18-year CHD and all-cause mortality, above and beyond the SUA levels proper.
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