ArticlePLoS neglected tropical diseases2019
Antifungal compounds from Streptomyces associated with attine ants also inhibit Leishmania donovani.
Article in PLoS neglected tropical diseases, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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22 citing papers in PubMed, 58 citations in OpenAlex.
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- Symbiosis, dysbiosis and the impact of horizontal exchange on bacterial microbiomes in higher fungus-gardening ants.Scientific reports · 2024Article
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- Characterizing corn-straw-degrading actinomycetes and evaluating application efficiency in straw-returning experiments.Frontiers in microbiology · 2022Article
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- Microorganisms as a Potential Source of Molecules to Control Trypanosomatid Diseases.Molecules (Basel, Switzerland) · 2021Review
- Antibacterial Potential of Termite-AssociatedACS omega · 2021Article
- Antileishmanial macrolides from ant-associated Streptomyces sp. ISID311.Bioorganic & medicinal chemistry · 2021Article
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- PF-429242, a Subtilisin Inhibitor, Is EffectiveFrontiers in microbiology · 2021Article
- Chemical warfare between fungus-growing ants and their pathogens.Current opinion in chemical biology · 2020Review
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Authors and funding
9 authors at 2 institutions in 2 countries.
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Abstract
Bacterial strains isolated from attine ants showed activity against the insect specialized fungal pathogen Escovopsis and also against the human protozoan parasite Leishmania donovani. The bioassay guided fractionation of extracts from cultures of Streptomyces sp. ICBG292, isolated from the exoskeleton of Cyphomyrmex workers, led to the isolation of Mer-A2026B (1), piericidin-A1 (2) and nigericin (3). Nigericin (3) presented high activity against intracellular amastigotes of L. donovani (IC50 0.129 ± 0.008 μM). Streptomyces puniceus ICBG378, isolated from workers of Acromyrmex rugosus rugosus, produced dinactin (4) with potent anti-L. donovani activity against intracellular amastigotes (IC50 0.018 ± 0.003 μM). Compounds 3 and 4 showed good selectivity indexes, 88.91 and 656.11 respectively, and were more active than positive control, miltefosine. Compounds 1-4 were also active against some Escovopsis strains. Compounds 1 and 2 were also produced by Streptomyces sp. ICBG233, isolated from workers of Atta sexdens, and detected in ants' extracts by mass spectrometry, suggesting they are produced in the natural environment as defensive compounds involved in the symbiotic interaction.
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