ArticleJournal of Parkinson's disease2019
Small Fibre Neuropathy in Parkinson's Disease: Comparison of Skin Biopsies from the More Affected and Less Affected Sides.
Article in Journal of Parkinson's disease, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 22 citations in OpenAlex.
- Pain in Parkinson's disease: bridging pathophysiology, clinical features, and personalized management.The journal of headache and pain · 2026Review
- Comment on "Electrophysiological and Biochemical Evaluations of Neuropathy Risk in Oral Levodopa versus Levodopa/Carbidopa Intestinal Gel Treatment".Arquivos de neuro-psiquiatria · 2026Article
- Cutaneous α-Synuclein Pathology as a Differential Marker: A Histological and Statistical Comparison across Neurodegenerative Disease Groups.Journal of molecular neuroscience : MN · 2026Article
- Exploring the skin as an open window onto neurodegenerative diseases.Translational neurodegeneration · 2025Review
- Cutaneous nerve fiber pathology and function in Parkinson's disease and atypical parkinsonism - a cohort study.NPJ Parkinson's disease · 2025Article
- In vivo confocal microscopy provides evidence of corneal nerve damage and basal tear film reduction in patients treated with oral isotretinoin.Journal of translational medicine · 2025Article
- Article
- Knowledge, Awareness, and Attitude of Healthcare Stakeholders on Alzheimer's Disease and Dementia in Qatar.International journal of environmental research and public health · 2023Review
- Recovery of Corneal Innervation after Treatment in Dry Eye Disease: A Confocal Microscopy Study.Journal of clinical medicine · 2023Article
- Small fiber neuropathy as a complication of SARS-CoV-2 vaccinations.Journal of family medicine and primary care · 2022Article
- Small fiber neuropathy in the cornea of Covid-19 patients associated with the generation of ocular surface disease.The ocular surface · 2022Observational
- Proinflammatory profile in the skin of Parkinson's disease patients with and without pain.PloS one · 2022Article
- Parkinson's disease with restless legs syndrome-an in vivo corneal confocal microscopy study.NPJ Parkinson's disease · 2021Article
- Neuro-Immunity and Gut Dysbiosis Drive Parkinson's Disease-Induced Pain.Frontiers in immunology · 2021Review
- Role of the Peripheral Nervous System in PD Pathology, Diagnosis, and Treatment.Frontiers in neuroscience · 2021Review
- Potential use of corneal confocal microscopy in the diagnosis of Parkinson's disease associated neuropathy.Translational neurodegeneration · 2020Review
- Neuropathy in Parkinson's Disease. Comment: Neuropathy in Parkinson's Disease: Risk Determinants and Impact on Quality of Life.Annals of Indian Academy of NeurologyArticle
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
Abstract
We assessed small nerve fibre degeneration and regeneration in more and less affected sides in Parkinson's disease (PD). Bilateral skin biopsies from 23 PD patients were immunostained for PGP9.5 for Intraepidermal Nerve Fibre Density (IENFD) and GAP-43 for mean axonal length (MAL), total epidermal (TNFL) and subepidermal nerve fibre length (SKTNFL). IENFD (p < 0.001) and SKTNFL (p < 0.001) were lower, whilst MAL (p < 0.001) and TNFL (p < 0.05) were higher in more affected versus less affected side. These results suggest increased small nerve fibre degeneration accompanied by enhanced nerve regeneration on the side more affected by PD and GAP-43 usefulness in skin biopsy assessment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.