Evidence map›Paper›PMID 31381423›Full record

ArticleCirculation2019

Functionally Competent DNA Damage-Free Induced Pluripotent Stem Cell-Derived Cardiomyocytes for Myocardial Repair.

Ramaswamy Kannappan, James F Turner, Jessica M Miller, Chengming Fan, Amanda G Rushdi, Namakkal Soorappan Rajasekaran, Jianyi Zhang

Abstract readLetter
PubMed Full text at PMC Publisher
In one paragraph

Article in Circulation, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. To Repair a Broken Heart: Stem Cells in Ischemic Heart Disease.Current issues in molecular biology · 2024
    Review
  2. Sealing the heart from the inside out.Nature biomedical engineering · 2023
    Article
  3. Article
  4. Article
  5. Review
  6. DNA damage-free iPS cells exhibit potential to yield competent cardiomyocytes.American journal of physiology. Heart and circulatory physiology · 2020
    Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ramaswamy KannappanDepartment of Biomedical Engineering, School of Engineering (R.K., J.F.T., J.M.M., C.F., A.G.R., N.S.R., J.Z.), School of Medicine, The University of Alabama at Birmingham.
James F TurnerDepartment of Biomedical Engineering, School of Engineering (R.K., J.F.T., J.M.M., C.F., A.G.R., N.S.R., J.Z.), School of Medicine, The University of Alabama at Birmingham.
Jessica M MillerDepartment of Biomedical Engineering, School of Engineering (R.K., J.F.T., J.M.M., C.F., A.G.R., N.S.R., J.Z.), School of Medicine, The University of Alabama at Birmingham.
Chengming FanDepartment of Biomedical Engineering, School of Engineering (R.K., J.F.T., J.M.M., C.F., A.G.R., N.S.R., J.Z.), School of Medicine, The University of Alabama at Birmingham.
Amanda G RushdiDepartment of Biomedical Engineering, School of Engineering (R.K., J.F.T., J.M.M., C.F., A.G.R., N.S.R., J.Z.), School of Medicine, The University of Alabama at Birmingham.
Namakkal Soorappan RajasekaranDepartment of Biomedical Engineering, School of Engineering (R.K., J.F.T., J.M.M., C.F., A.G.R., N.S.R., J.Z.), School of Medicine, The University of Alabama at Birmingham.
Jianyi ZhangDepartment of Biomedical Engineering, School of Engineering (R.K., J.F.T., J.M.M., C.F., A.G.R., N.S.R., J.Z.), School of Medicine, The University of Alabama at Birmingham.

Funding

University of Alabama at Birmingham's Diabetes Research CenterP30DK079626 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Kirk Michael Habegger · 2013 to 2026
$19.5M
Integrated Cellular and Tissue Engineering for Ischemic Heart DiseaseU01HL134764 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI BURSAC, NENAD, KAMP, TIMOTHY J. · 2016 to 2022
$7.7M
Supplement of HL131017: Myocardial remuscularization by cardiac patch delivery of epicardial FSTL1 and CCND2 overexpressing cardiomyocytesR01HL131017 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI SERPOOSHAN, VAHID, ZHANG, JIANYI · 2016 to 2025
$5.8M
Endogenous and exogenous mechanisms that promote myocardial remuscularization in post infarction LV remodelingR01HL114120 · NHLBI · UNIVERSITY OF MINNESOTA · PI ZHANG, JIANYI · 2012 to 2021
$5.6M
Reductive Stress Induces Proteotoxic Cardiac DiseaseR01HL118067 · NHLBI · UNIVERSITY OF UTAH · PI NAMAKKAL SOORAPPAN, RAJASEKARAN · 2013 to 2021
$4.5M
Stem Cells For Myocardial Repair: A Large Bore Magnet StudyR01HL095077 · NHLBI · UNIVERSITY OF MINNESOTA · PI ZHANG, JIANYI · 2009 to 2017
$3.8M
Mesenchymal Stem Cell Exosome in Efferocytosis of Apoptotic Cardiomyocytes and Repair after Myocardial IschemiaR01HL138023 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI KRISHNAMURTHY, PRASANNA, ZHANG, JIANYI · 2018 to 2021
$2.6M
American Heart Association-American Stroke Association 17SDG33670677NHLBI NIH HHS R01 HL095077NHLBI NIH HHS R01 HL114120NHLBI NIH HHS R01 HL118067NHLBI NIH HHS R01 HL131017NHLBI NIH HHS R01 HL138023NHLBI NIH HHS U01 HL134764NIDDK NIH HHS P30 DK079626
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

DNA DamageAnimalsApoptosisCell DifferentiationCell SeparationCoronary StenosisCoronary VesselsDisease Models, AnimalGenes, p53Graft SurvivalImidazolesInduced Pluripotent Stem CellsLigationMiceMice, SCIDMyocytes, CardiacImidazolesnutlin 3Piperazinescardiac myocytesDNA damagepluripotent stem cellsTP53

Identifiers

PMID31381423
PMCPMC6686875

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.