ArticleObesity (Silver Spring, Md.)2019
Overweight Patterns Between Childhood and Early Adulthood and Esophageal and Gastric Cardia Adenocarcinoma Risk.
Article in Obesity (Silver Spring, Md.), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.
- Association of childhood and adolescence obesity with incidence and mortality of adulthood cancers. A systematic review and meta-analysis.Frontiers in endocrinology · 2023Pooled it
- Body size and occupational physical activity during the life course and gastrointestinal cancers.American journal of epidemiology · 2025Article
- Are associations of adulthood overweight and obesity with all-cause mortality, cardiovascular disease, and obesity-related cancer modified by comparative body weight at age 10 years in the UK Biobank study?International journal of obesity (2005) · 2025Article
- Is early-life obesity associated with kidney cancer in adulthood?-insights from genetic studies.Translational andrology and urology · 2025Article
- Does childhood obesity foreshadow a future time-bomb of early and more aggressive cancers?Frontiers in endocrinology · 2025Review
- Early-life exposures and adulthood cancer risk: A life course perspective.Journal of the National Cancer Institute · 2023Article
- Risk of Presenting with Poor-Prognosis Metastatic Cancer in Adolescents and Young Adults: A Population-Based Study.Cancers · 2022Article
- Obesity during childhood is associated with higher cancer mortality rate during adulthood: the i3C Consortium.International journal of obesity (2005) · 2022Article
- Obesity at early adulthood increases risk of gastric cancer from the Health Examinees-Gem (HEXA-G) study.PloS one · 2022Article
- Birthweight, childhood overweight, height and growth and adult cancer risks: a review of studies using the Copenhagen School Health Records Register.International journal of obesity (2005) · 2020Review
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
objectiveEsophageal adenocarcinoma (EA) and gastric cardia adenocarcinoma (GCA) are among the most rapidly increasing cancers in Western countries. Elevated BMI in adulthood is a known risk factor, but associations in early life are unclear.
methodsThis study assessed weight change between childhood and early adulthood in relation to EA/GCA. Measured weights and heights during childhood (7-13 years) and early adulthood (17-26 years) were available for 64,695 young men from the Copenhagen School Health Records Register and the Danish Conscription Database. Individuals were categorized as having normal weight or overweight. Linkage with the Danish Cancer Registry identified 275 EA/GCA cases. Hazard ratios (HR) and 95% CI were estimated using Cox proportional hazards regression.
resultsThe risk of EA/GCA was 2.5 times higher in men who were first classified as having overweight at age 7 (HR = 2.49; 95% CI: 1.50-4.14) compared with men who were never classified as having overweight. Men who had persistent overweight at ages 7 and 13 and in early adulthood had an EA/GCA risk that was 3.2 times higher (HR = 3.18; 95% CI: 1.57-6.44). However, there was little evidence of increased EA/GCA risk for men with overweight during childhood and subsequent remittance by early adulthood.
conclusionsPersistent overweight in early life is associated with increased EA/GCA risk, which declines if body weight is reduced.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.