Evidence map›Paper›PMID 31380464›Full record

ArticleMolecular therapy. Methods & clinical development2019

Neuronal Activation Stimulates Cytomegalovirus Promoter-Driven Transgene Expression.

Susanne Bäck, Amanda Dossat, Ilmari Parkkinen, Pyry Koivula, Mikko Airavaara, Christopher T Richie, Yun-Hsiang Chen, Yun Wang, Brandon K Harvey

Open access · goldAbstract read
In one paragraph

Article in Molecular therapy. Methods & clinical development, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 22 citations in OpenAlex.

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  11. AAV vector development, back to the future.Molecular therapy : the journal of the American Society of Gene Therapy · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 3 countries.

Susanne BäckMolecular Mechanisms of Cellular Stress and Inflammation Section, National Institute on Drug Abuse, NIH, Baltimore, MD 21224, USA.
Amanda DossatMolecular Mechanisms of Cellular Stress and Inflammation Section, National Institute on Drug Abuse, NIH, Baltimore, MD 21224, USA.
Ilmari ParkkinenInstitute of Biotechnology, HILife Unit, University of Helsinki, 00014 Helsinki, Finland.
Pyry KoivulaMolecular Mechanisms of Cellular Stress and Inflammation Section, National Institute on Drug Abuse, NIH, Baltimore, MD 21224, USA.
Mikko AiravaaraInstitute of Biotechnology, HILife Unit, University of Helsinki, 00014 Helsinki, Finland.
Christopher T RichieGenetic Engineering and Viral Vector Core, National Institute on Drug Abuse, NIH, Baltimore, MD 21224, USA.
Yun-Hsiang ChenCenter for Neuropsychiatric Research, National Health Research Institutes, Zhunan, Taiwan.
Yun WangCenter for Neuropsychiatric Research, National Health Research Institutes, Zhunan, Taiwan.
Brandon K HarveyMolecular Mechanisms of Cellular Stress and Inflammation Section, National Institute on Drug Abuse, NIH, Baltimore, MD 21224, USA.
National Institute on Drug Abuse · USNational Health Research Institutes · TWUniversity of Helsinki · FI

Funding

Cellular mechanisms of neuronal dysfunction in addiction and neurodegenerationZIADA000618 · NIDA · NATIONAL INSTITUTE ON DRUG ABUSE · PI HARVEY, BRANDON · 2017 to 2025
$12.9M
Gene Therapy And NeurodegenerationZIADA000443 · NIDA · NATIONAL INSTITUTE ON DRUG ABUSE · PI HARVEY, BRANDON · 2009 to 2020
$2.7M
6 · The paper itself

Abstract

The cytomegalovirus (CMV) immediate early promoter has been extensively developed and exploited for transgene expression

Identifiers

PMID31380464
PMCPMC6661544
OpenAlexW2953668380

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.