ArticleBioMed research international2019
Relationship between Endplate Defects, Modic Change, Disc Degeneration, and Facet Joint Degeneration in Patients with Low Back Pain.
Article in BioMed research international, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
25 citing papers in PubMed, 38 citations in OpenAlex.
- Correlation between Magnetic Resonance Imaging Modic Endplate Changes and Histopathological Inflammatory Activity in Lumbar Degenerative Disc Disease.Journal of orthopaedic case reports · 2026Article
- Association between vertebral endplate lesions and sagittal spinal alignment: a retrospective imaging analysis in a selected adult patient population.European radiology experimental · 2026Article
- Association between multifidus fatty infiltration and lumbar facet degeneration in unilateral disc herniation: a retrospective study.Journal of orthopaedic surgery and research · 2026Article
- Prevalence of modic changes in patients with low back pain and association with degenerative spinal findings: a retrospective MRI study.BMC musculoskeletal disorders · 2025Article
- Role of macrophage in intervertebral disc degeneration.Bone research · 2025Review
- LTF ameliorates cartilage endplate degeneration by suppressing calcification, senescence and matrix degradation through the JAK2/STAT3 pathway.Journal of cellular and molecular medicine · 2024Article
- Exploration of the correlation between facet joints cross-sectional area asymmetry and cervical disc herniation.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2024Article
- Are serum thyroid hormone, parathormone, calcium, and vitamin D levels associated with lumbar spine degeneration? A cross-sectional observational clinical study.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2023Article
- Subjective assessment and biochemical evaluation of traction therapy in women with chronic low back pain: does body mass index matter? A clinical study.BMC musculoskeletal disorders · 2023Article
- Correlation between posterior paraspinal muscle atrophy and lumbar intervertebral disc degeneration in patients with chronic low back pain.International orthopaedics · 2023Article
- Endplate role in the degenerative disc disease: A brief review.World journal of clinical cases · 2023Review
- Vertebrogenic Pain: A Paradigm Shift in Diagnosis and Treatment of Axial Low Back Pain.Pain medicine (Malden, Mass.) · 2022Article
- Evaluation the association of facet tropism in multi-sports athletes with cervical disc hernia.BMC musculoskeletal disorders · 2022Article
- Factors associated with low back pain in patients with lumbar spinal stenosis: a cross-sectional study.BMC musculoskeletal disorders · 2022Article
- The Endplate Role in Degenerative Disc Disease Research: The Isolation of Human Chondrocytes from Vertebral Endplate-An Optimised Protocol.Bioengineering (Basel, Switzerland) · 2022Article
- Analysis of Chronic Low Back Pain Caused by Lumbar Microinstability After Percutaneous Endoscopic Transforaminal Discectomy: A Retrospective Study.Journal of pain research · 2022Article
- Experimental Rat Model of Bony Defects in the Facet Joint Maintained with Bone Wax for the Study of Spinal Pain.Journal of pain research · 2022Article
- The Role of Diagnostic Injections in Spinal Disorders: A Narrative Review.Diagnostics (Basel, Switzerland) · 2021Review
- Comprehensive analysis of N6-methyladenosine (mJournal of orthopaedic translation · 2021Article
- Role of microRNAs in intervertebral disc degeneration (Review).Experimental and therapeutic medicine · 2021Review
Corrections and comments
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Authors and funding
13 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe endplate defects (EDs), Modic changes (MCs), disc degeneration (DD), facet orientation (FO), and facet tropism (FT) were demonstrated to be related to the low back pain (LBP). The aim of this study was to investigate possible correlations between them.
methods75 patients were reviewed to evaluate the degenerative change in vertebral bodies (EDs and MCs), intervertebral discs (DD), and facet joint degeneration (FO and FT). All patients were categorized into four groups based on the grade of EDs. Clinical outcomes were evaluated with the visual analog scale (VAS) and Oswestry disability index (ODI) before and after surgery.
resultsThere was no difference between the four groups in baseline characteristics except for gender and weight. FT is positively correlated with FO. The same rule exists between EDs, the size of MCs II, FO (left) and FO (right), and VAS and ODI. The grade of EDs is positively correlated with the grade of DD. L4-L5 can bear more load than other levels; thus, the grade of EDs is higher than that of other lumbar levels. The preoperative LBP was relieved in all groups in varying degrees. The change of pain and dysfunction is inversely proportional to the grade of EDs in the general trend.
conclusionThe relationship between weight, gender, and disc degeneration provided a mechanism by which increasing weight can predispose to DD. Different grades of EDs had different effects on patients with LBP. There was a significant correlation between EDs, MCs II, DD, FT, and FO.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.