ArticleBioMed research international2019
Regular Music Exposure in Juvenile Rats Facilitates Conditioned Fear Extinction and Reduces Anxiety after Foot Shock in Adulthood.
Article in BioMed research international, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 20 citations in OpenAlex.
- Effects of Classical Music on Behavioral and Physiological Stress Markers in Socially Isolated Prairie Voles.Annals of the New York Academy of Sciences · 2026Article
- A novel finding on sex-dependent diverse behavioral responses to the anticipation of a threat in a rat model of fear conditioning with the involvement of brain-derived neurotrophic factor (BDNF) in the prefrontal cortex.Learning & behavior · 2026Article
- Review
- Effects of Different Ways of Music Stimulation on Exploring, Playing and Aggressive Behavior.Animals : an open access journal from MDPI · 2025Article
- Investigation of the Mozart sonata effect on contextual memory extinction.Einstein (Sao Paulo, Brazil) · 2025Article
- Effects of Raga music and Chinese five-element on milk production, antioxidant, neuroendocrine, immune, and welfare indicators in dairy cows.Frontiers in veterinary science · 2025Article
- Review
- Music with Different Tones Affects the Development of Brain Nerves in Mice in Early Life through BDNF and Its Downstream Pathways.International journal of molecular sciences · 2023Article
- Animal Signals, Music and Emotional Well-Being.Animals : an open access journal from MDPI · 2021Review
- Review
- Corticosterone Induced the Increase of proBDNF in Primary Hippocampal Neurons Via Endoplasmic Reticulum Stress.Neurotoxicity research · 2020Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Music exposure is known to play a positive role in learning and memory and can be a complementary treatment for anxiety and fear. However, whether juvenile music exposure affects adult behavior is not known. Two-week-old Sprague-Dawley rats were exposed to music for 2 hours daily or to background noise (controls) for a period of 3 weeks. At 60 days of age, rats were subjected to auditory fear conditioning, fear extinction training, and anxiety-like behavior assessments or to anterior cingulate cortex (ACC) brain-derived neurotrophic factor (BDNF) assays. We found that the music-exposed rats showed significantly less freezing behaviors during fear extinction training and spent more time in the open arm of the elevated plus maze after fear conditioning when compared with the control rats. Moreover, the BDNF levels in the ACC in the music group were significantly higher than those of the controls with the fear conditioning session. This result suggests that music exposure in juvenile rats decreases anxiety-like behaviors, facilitates fear extinction, and increases BDNF levels in the ACC in adulthood after a stressful event.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.