ArticleBioMed research international2019
The Mechanical Interpretation of Ocular Response Analyzer Parameters.
Article in BioMed research international, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 22 citations in OpenAlex.
- Adaptive Temporal Mixture of Experts for Predicting Stiffness Metrics From the Ocular Response Analyzer and Identifying Keratoconus.American journal of ophthalmology · 2026Observational
- Corneal Biomechanics in Glaucoma: Current Evidence for Diagnosis, Risk Stratification, and Prognosis.Clinical ophthalmology (Auckland, N.Z.) · 2026Review
- Comparative corneal biomechanical changes after FS-LASIK and orthokeratology.Biomedical engineering online · 2025Article
- The Impact of Small Incision Lenticule Extraction on the Biomechanical Properties of the Cornea: A Review.Bioengineering (Basel, Switzerland) · 2025Review
- Evaluating corneal cross-linking using Stress-Strain Index maps: a finite element study.Journal of the Royal Society, Interface · 2025Article
- Corrigendum to "The Mechanical Interpretation of Ocular Response Analyzer Parameters".BioMed research international · 2025Article
- Accuracy of a novel method for IOP measurement without applying pressure on the cornea.International ophthalmology · 2024Article
- Corneal biomechanics and diagnostics: a review.International ophthalmology · 2024Review
- Keratoconus cone location influences ocular biomechanical parameters measured by the Ocular Response Analyzer.Eye and vision (London, England) · 2024Article
- Corneal and intraocular pressure changes associated to the circadian rhythms: a narrative review.International journal of ophthalmology · 2024Review
- Determine Corneal Biomechanical Parameters by Finite Element Simulation and Parametric Analysis Based on ORA Measurements.Frontiers in bioengineering and biotechnology · 2022Article
- Identification of Peripheral Anterior Synechia by Corneal Deformation Using Air-Puff Dynamic Anterior Segment Optical Coherence Tomography.Frontiers in bioengineering and biotechnology · 2022Article
- Exploring the Biomechanical Properties of the Human CorneaFrontiers in bioengineering and biotechnology · 2021Article
- Relationship between Corneal Morphogeometrical Properties and Biomechanical Parameters Derived from Dynamic Bidirectional Air Applanation Measurement Procedure in Keratoconus.Diagnostics (Basel, Switzerland) · 2020Article
- Corneal Biomechanics as a Causal Factor in Myopia and Astigmatism: Evidence from Mendelian Randomization.Ophthalmology scienceArticle
- The influence of ocular parameters on intraocular pressure values measured by different devices and the development of an optimized prediction model in a myopic population.Advances in ophthalmology practice and researchArticle
Corrections and comments
- Erratum issued
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeOcular Response Analyzer (ORA) is one of the most widely used devices in clinic, while the mechanical interpretations of parameters obtained from ORA have not been understood completely. The aim of this research is to explore the mechanical interpretation of ORA parameters.
methodsRabbits aged 3-24 months were measured with ORA in vivo and corneal strips uniaxial tensile tests to get ORA parameters and corneal biomechanical parameters (corneal elastic modulus, relaxation time, and relaxation limit). The mechanical interpretation of ORA parameters was cognized preliminarily by analyzing the correlation between ORA parameters and corneal biomechanical parameters. On the other hand, finite element method was applied to simulate ORA measurements with different corneal biomechanical parameters to obtain quantitative relationship between ORA parameters and corneal biomechanical parameters further.
resultsBiomechanical experimental results showed that Corneal Resistance Factor (CRF) was correlated with corneal elastic modulus and relaxation limit significantly, while the significant correlations between Corneal Hysteresis (CH) and corneal biomechanical parameters were not observed. Results of finite element analysis showed that both CH and CRF were correlated with corneal elastic modulus, relaxation limit, and relaxation time significantly. Besides, corneal elastic modulus was positively correlated with
conclusionsFor all ORA parameters, CH, CRF, the upslope, and the width of the peaks are parameters which may reflect corneal elastic properties. It is viable to cognize mechanical interpretation of ORA parameters by the comparisons of the data from ORA and biomechanical tests of rabbits with different ages and the simulations of ORA based on finite element methods. Further studies are needed to confirm the mechanical interpretation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.