Evidence map›Paper›PMID 31380412›Full record

ArticleBioMed research international2019

Transcription Factor IRF4 Dysfunction Affects the Immunosuppressive Function of Treg Cells in Patients with Primary Immune Thrombocytopenia.

Meiwen Tang, Luya Cheng, Feng Li, Boting Wu, Pu Chen, Yanxia Zhan, Fanli Hua, Zhihui Min, Yang Ke, Chanjuan Liu and 5 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BioMed research international, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 20 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 2 institutions in 1 country.

Meiwen TangDepartment of Hematology, Zhongshan Hospital Fudan University, Shanghai 200032, China.
Luya ChengDepartment of Hematology, Zhongshan Hospital Fudan University, Shanghai 200032, China.
Feng LiDepartment of Hematology, Zhongshan Hospital Fudan University, Shanghai 200032, China.
Boting WuDepartment of Transfusion Medicine, Zhongshan Hospital Fudan University, Shanghai 200032, China.
Pu ChenDepartment of Clinical Laboratory, Zhongshan Hospital Fudan University, Shanghai 200032, China.
Yanxia ZhanDepartment of Hematology, Zhongshan Hospital Fudan University, Shanghai 200032, China.
Fanli HuaDepartment of Hematology, Zhongshan Hospital Qinpu Branch, Fudan University, Shanghai 201700, China.
Zhihui MinInstitute of Clinical Science, Zhongshan Hospital Fudan University, Shanghai 200032, China.
Yang KeDepartment of Hematology, Zhongshan Hospital Fudan University, Shanghai 200032, China.
Chanjuan LiuDepartment of Hematology, Zhongshan Hospital Fudan University, Shanghai 200032, China.
Ling YuanDepartment of Hematology, Zhongshan Hospital Fudan University, Shanghai 200032, China.
Lihua SunDepartment of Hematology, Zhongshan Hospital Qinpu Branch, Fudan University, Shanghai 201700, China.
Hao ChenDepartment of Thoracic Surgery, Zhongshan Hospital Xuhui Branch, Fudan University, Shanghai 200031, China.ORCID https://orcid.org/0000-0003-2786-9892
Lili JiDepartment of Hematology, Zhongshan Hospital Fudan University, Shanghai 200032, China.ORCID https://orcid.org/0000-0003-3618-0683
Yunfeng ChengDepartment of Hematology, Zhongshan Hospital Fudan University, Shanghai 200032, China.ORCID https://orcid.org/0000-0002-9581-1134
Sun Yat-sen University · CNFudan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTh17/Treg balance skews towards Th17 in ITP patient. IRF4 has been highlighted for its close relationship to the immunosuppressive function of Treg cells and the IL-17 synthesis in CD4

methodsTreg and Teff cells were isolated from PBMCs of newly diagnosed ITP patients. The percentages of CD4

resultsThe secretion of IL-10 by Tregs was decreased in ITP patients. The intensity of IRF4 binding to IL-10 DNA of Tregs in patients was higher than that of normal controls and Teffs in ITP patients. The expressions of IRF4 of Tregs in ITP patients were remarkably lower than that of healthy controls. The percentage of Th17 cells in healthy controls was significantly increased after IRF4 mRNA silencing. Abnormal metabolism of Treg and Teff cells was found in ITP patients.

conclusionThe skewed ratio of Th17/Treg cells and dysfunction of Treg cells in newly diagnosed ITP patients was at least partly caused by IRF4 dysfunction. The underlying mechanism might be the impact of IRF4 on the metabolism of Treg and Teff cells.

Indexed as

AdultAgedCD4-Positive T-LymphocytesFemaleGene Expression RegulationHumansImmunosuppression TherapyInterferon Regulatory Factor-4Interferon Regulatory FactorsInterleukin-10MaleMiddle AgedProtein BindingPurpura, Thrombocytopenic, IdiopathicTh17 CellsT-Lymphocytes, RegulatoryInterferon Regulatory Factor-4Interferon Regulatory FactorsInterleukin-10

Identifiers

PMID31380412
PMCPMC6652070
OpenAlexW2961364472

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.