Evidence map›Paper›PMID 31380382›Full record

ArticleFrontiers in medicine2019

Novel Microbial-Based Immunotherapy Approach for Crohn's Disease.

Simon Sutcliffe, Shirin Kalyan, Jim Pankovich, Jenny M H Chen, Rashieda Gluck, Darby Thompson, Momir Bosiljcic, Mark Bazett, Richard N Fedorak, Remo Panaccione and 10 more

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05677113 (A Phase II Study of Perioperative QBECO Site Specific Immunomodulator), which is not on this map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.9field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05677113 phase2active not recruitingnot on this mapstarted 2023, after this paper: background citation

A Phase II Study of Perioperative QBECO Site Specific Immunomodulator (Qu Biologics®) in Patients With Metastatic Colorectal Adenocarcinoma Within the Liver Undergoing Resection

TypeinterventionalSponsorSunnybrook Health Sciences CentreRan2023 to 2031Enrolled115ConditionsColorectal Cancer, Liver MetastasesArmsQBECO, Placebo
3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 10 institutions in 2 countries.

Simon SutcliffeQu Biologics Inc., Vancouver, BC, Canada.
Shirin KalyanQu Biologics Inc., Vancouver, BC, Canada.
Jim PankovichQu Biologics Inc., Vancouver, BC, Canada.
Jenny M H ChenQu Biologics Inc., Vancouver, BC, Canada.
Rashieda GluckQu Biologics Inc., Vancouver, BC, Canada.
Darby ThompsonEmmes Canada, Burnaby, BC, Canada.
Momir BosiljcicQu Biologics Inc., Vancouver, BC, Canada.
Mark BazettQu Biologics Inc., Vancouver, BC, Canada.
Richard N FedorakDivision of Gastroenterology, University of Alberta, Edmonton, AB, Canada.
Remo PanaccioneInflammatory Bowel Disease Unit, University of Calgary, Calgary, AB, Canada.
Jeffrey AxlerToronto Digestive Disease Associates Inc., Vaughan, ON, Canada.
John K MarshallDepartment of Medicine and Farncombe Family Digestive Health Research Institute, McMaster University, Hamilton, ON, Canada.
David W MullinsDepartment of Microbiology, Immunology and Medical Education, Geisel School of Medicine at Dartmouth, Hanover, NH, United States.
Boyko KabakchievZane Cohen Centre for Digestive Diseases, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, ON, Canada.
Dermot P B McGovernCedars-Sinai Medical Center, Los Angeles, CA, United States.
Julie JangQu Biologics Inc., Vancouver, BC, Canada.
Andrew ColdmanCancer Control Research, British Columbia Cancer Agency, Vancouver, BC, Canada.
Gillian VandermeirschQu Biologics Inc., Vancouver, BC, Canada.
Brian BresslerGastrointestinal Research Institute, Vancouver, BC, Canada.
Hal GunnQu Biologics Inc., Vancouver, BC, Canada.
BC Cancer Agency · CACanadian Society of Intestinal Research · CACedars-Sinai Medical Center · USDartmouth College · USMcMaster University · CAMount Sinai Hospital · CASimon Fraser University · CAUniversity of Alberta · CAUniversity of British Columbia · CAUniversity of Calgary · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

biologicbiomarkersCrohn's diseaseimmunotherapyinnate immunitymicrobial-based therapyrandomized placebo-controlled trial

Identifiers

PMID31380382
PMCPMC6659126
OpenAlexW2959492986

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.