ArticleFrontiers in chemistry2019
Tuning the Solubility of Self-Assembled Fluorescent Aromatic Cages Using Functionalized Amino Acid Building Blocks.
Article in Frontiers in chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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Who cites it
6 citing papers in PubMed, 20 citations in OpenAlex.
- Axial Chirality Induction in Ferrocene-Amino Acid Hybrids─toward Chiral Redox-Active Building Blocks.Inorganic chemistry · 2026Article
- Peptide cages: bioinspired supramolecular architectures for next-generation applications.Chemical science · 2026Review
- Dynamic covalent synthesis.Chemical science · 2024Review
- Purely Covalent Molecular Cages and Containers for Guest Encapsulation.Chemical reviews · 2022Review
- A Fluorescent Cage for Supramolecular Sensing of 3-Nitrotyrosine in Human Blood Serum.Angewandte Chemie (International ed. in English) · 2022Article
- Expanding structural diversity in a library of disulfide macrocycles through in-situ imide hydrolysis.Scientific reports · 2022Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We previously reported novel fluorescent aromatic cages that are self-produced using a set of orthogonal dynamic covalent reactions, operating simultaneously in one-pot, to assemble up to 10 components through 12 reactions into a single cage-type structure. We now introduce N-functionalized amino acids as new building blocks that enable tuning the solubility and analysis of the resulting cages. A convenient divergent synthetic approach was developed to tether different side chains on the N-terminal of a cysteine-derived building block. Our studies show that this chemical functionalization does not prevent the subsequent self-assembly and effective formation of desired cages. While the originally described cages required 94% DMSO, the new ones bearing hydrophobic side chains were found soluble in organic solvents (up to 75% CHCl
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Registered trials
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