ArticleFrontiers in oncology2019
Confocal-Assisted Multispectral Fluorescent Microscopy for Brain Tumor Surgery.
Article in Frontiers in oncology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 47 citations in OpenAlex.
- Fluorescein-stained confocal laser endomicroscopy versus conventional frozen section for intraoperative histopathological assessment of intracranial tumors.Neuro-oncology · 2024Trial
- Stable distance regression via spatial-frequency state space model for robot-assisted endomicroscopy.International journal of computer assisted radiology and surgery · 2025Article
- Multimodal imaging platform for enhanced tumor resection in neurosurgery: integrating hyperspectral and pCLE technologies.International journal of computer assisted radiology and surgery · 2025Article
- Envisioning the Future of the Neurosurgical Operating Room with the Concept of the Medical Metaverse.Journal of Korean Neurosurgical Society · 2025Article
- Confocal Laser Endomicroscopy: Enhancing Intraoperative Decision Making in Neurosurgery.Diagnostics (Basel, Switzerland) · 2025Review
- Clinical application of confocal laser endomicroscopy in neurosurgery: a scoping review.Frontiers in surgery · 2025Review
- Fluorescence saturation imaging microscopy: molecular fingerprinting with a standard confocal microscope.Biomedical optics express · 2024Article
- FF-ViT: probe orientation regression for robot-assisted endomicroscopy tissue scanning.International journal of computer assisted radiology and surgery · 2024Article
- A prospective multicenter assessor blinded pilot study using confocal laser endomicroscopy for intraoperative brain tumor diagnosis.Scientific reports · 2024Article
- Nanotechnology: A Promising Targeted Drug Delivery System for Brain Tumours and Alzheimer's Disease.Current medicinal chemistry · 2023Review
- Meningiomas with CNS invasion.Frontiers in neuroscience · 2023Review
- Development, Implementation and Application of Confocal Laser Endomicroscopy in Brain, Head and Neck Surgery-A Review.Diagnostics (Basel, Switzerland) · 2022Review
- Machine learning in neuro-oncology: toward novel development fields.Journal of neuro-oncology · 2022Review
- Near-infrared fluorescence imaging with indocyanine green for assessment of donor livers in a rat model of ischemia-reperfusion.BMC gastroenterology · 2022Article
- Clinical feasibility of miniaturized Lissajous scanning confocal laser endomicroscopy for indocyanine green-enhanced brain tumor diagnosis.Frontiers in oncology · 2022Article
- Confocal Laser Endomicroscopy in Oncological Surgery.Diagnostics (Basel, Switzerland) · 2021Article
- Confocal Laser Microscopy in Neurosurgery: State of the Art of Actual Clinical Applications.Journal of clinical medicine · 2021Review
- Intraoperative molecular imaging clinical trials: a review of 2020 conference proceedings.Journal of biomedical optics · 2021Review
- High frame rate video mosaicking microendoscope to image large regions of intact tissue with subcellular resolution.Biomedical optics express · 2021Article
- Deep Neural Network for Differentiation of Brain Tumor Tissue Displayed by Confocal Laser Endomicroscopy.Frontiers in oncology · 2021Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Optimal surgical therapy for brain tumors is the combination of complete resection with minimal invasion and damage to the adjacent normal tissue. To achieve this goal, we need advanced imaging techniques on a scale from macro- to microscopic resolution. In the last decade, the development of fluorescence-guided surgery has been the most influential breakthrough, marginally improving outcomes in brain tumor surgery. Multispectral fluorescence microscopy (MFL) is a novel imaging technique that allows the overlapping of a fluorescent image and a white light image in real-time, with delivery of the merged image to the surgeon through the eyepieces of a surgical microscope. MFL permits the detection and characterization of brain tumors using fluorescent molecular markers such as 5-aminolevulinic acid (5-ALA) or indocyanine green (ICG), while simultaneously obtaining high definition white light images to create a pseudo-colored composite image in real-time. Limitations associated with the use of MFL include decreased light imaging intensity and decreased levels of magnification that may compromise maximal tumor resection on a cellular scale. Confocal laser endomicroscopy (CLE) is another novel advanced imaging technique that is based on miniaturization of the microscope imaging head in order to provide the possibility of
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.