ReviewTranslational andrology and urology2019
Fertility concerns of the transgender patient.
Review in Translational andrology and urology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
45 citing papers in PubMed, 2 syntheses or guidelines pooled it, 144 citations in OpenAlex.
- Fertility preservation for transgender children and young people in paediatric healthcare: a systematic review of ethical considerations.Journal of medical ethics · 2022Pooled it
- Hormonal Gender Reassignment Treatment for Gender Dysphoria.Deutsches Arzteblatt international · 2020Pooled it
- Development of medical freezing measures in women during the last decade from 2014 to 2023: registry data of the tri-national network FertiPROTEKT.Archives of gynecology and obstetrics · 2026Article
- Structural stigma, parenthood patterns and depressive symptoms among transgender and gender diverse individuals across 30 countries in Europe.International journal of transgender health · 2026Article
- Access to Fertility Preservation: A Policy Review on State-Level Mandates for Iatrogenic Infertility.The Permanente journal · 2025Article
- ESHRE's key research priorities in infertility: maximizing impact on science, people and society†.Human reproduction (Oxford, England) · 2025Article
- The GnRH Agonist Triptorelin Causes Reversible, Focal, and Partial Testicular Atrophy in Rats, Maintaining Sperm Production.International journal of molecular sciences · 2025Article
- The Impact of a Formalized Fertility Preservation Program on Access to Care and Sperm Cryopreservation Among Transgender and Nonbinary Patients Assigned Male at Birth.Journal of clinical medicine · 2025Article
- Emerging and accumulating safety signals for the use of estrogen among transgender women.Discover mental health · 2025Review
- Transgender and gender diverse patients' experiences with pregnancy-related genetics discussions: A qualitative study.Journal of genetic counseling · 2025Article
- Exploring parenthood intentions and perceptions of infertility and assisted reproductive technology among 2SLGBTQIA + young adults in Ontario, Canada: a mixed methods study.Journal of health, population, and nutrition · 2025Article
- Psychodynamic psychotherapy for gender dysphoria is not conversion therapy.Journal of the Canadian Academy of Child and Adolescent Psychiatry = Journal de l'Academie canadienne de psychiatrie de l'enfant et de l'adolescent · 2024Article
- ESCAP statement on the care for children and adolescents with gender dysphoria: an urgent need for safeguarding clinical, scientific, and ethical standards.European child & adolescent psychiatry · 2024Article
- Gender Affirming Hormone Treatment for Trans Adolescents: A Four Principles Analysis.Journal of bioethical inquiry · 2024Article
- Neurological care for LGBT+ people.Nature reviews. Neurology · 2024Review
- Subjective Experiences of Pregnancy, Delivery, and Nursing in Transgender Men and Non-Binary Individuals: A Qualitative Analysis of Gender and Mental Health Concerns.Archives of sexual behavior · 2024Article
- Family Building in Transgender Patients: Modern Strategies with Assisted Reproductive Technology Treatment.Transgender health · 2024Article
- Clinical management of transgender and non-binary patients in the fertility preservation service: Current evidence.International journal of transgender health · 2024Review
- Clinicians in the Veterans Health Administration initiate gender-affirming hormone therapy in concordance with clinical guideline recommendations.Frontiers in endocrinology · 2024Article
- Medical decision-making competence regarding puberty suppression: perceptions of transgender adolescents, their parents and clinicians.European child & adolescent psychiatry · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Transgender individuals who undergo gender-affirming medical or surgical therapies are at risk for infertility. Suppression of puberty with gonadotropin-releasing hormone agonist analogs (GnRHa) in the pediatric transgender patient can pause the maturation of germ cells, and thus, affect fertility potential. Testosterone therapy in transgender men can suppress ovulation and alter ovarian histology, while estrogen therapy in transgender women can lead to impaired spermatogenesis and testicular atrophy. The effect of hormone therapy on fertility is potentially reversible, but the extent is unclear. Gender-affirming surgery (GAS) that includes hysterectomy and oophorectomy in transmen or orchiectomy in transwomen results in permanent sterility. It is recommended that clinicians counsel transgender patients on fertility preservation (FP) options prior to initiation of gender-affirming therapy. Transmen can choose to undergo cryopreservation of oocytes or embryos, which requires hormonal stimulation for egg retrieval. Uterus preservation allows transmen to gestate if desired. For transwomen, the option for FP is cryopreservation of sperm either through masturbation or testicular sperm extraction. Experimental and future options may include cryopreservation and
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.