ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2019
Driving Cells with Light-Controlled Topographies.
Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 35 citations in OpenAlex.
- Photo-guided azopolymer hydrogel actuators.Light, science & applications · 2026Article
- Skin Relevant Biomaterials from Wound Healing, Medical Aesthetics, Flexible Electronics to Artificial Intelligence and Beyond.Advanced materials (Deerfield Beach, Fla.) · 2026Review
- Directional flows using capillary assembly of photo-deformable colloidal particles at water-air interfaces.Nature communications · 2025Article
- Neuromorphic Light-Responsive Organic Matter for in Materia Reservoir Computing.Advanced materials (Deerfield Beach, Fla.) · 2025Article
- Photomechanical Azopolymers and Digital Polarization Optics: A Versatile Platform for Surface Microstructure Fabrication.ACS applied optical materials · 2025Review
- Assessing the stability of azopolymer nanotopography during live-cell fluorescence imaging.Frontiers in bioengineering and biotechnology · 2024Article
- Advances in Regulating Cellular Behavior Using Micropatterns.The Yale journal of biology and medicine · 2023Review
- Polarization-driven reversible actuation in a photo-responsive polymer composite.Nature communications · 2023Article
- Comparative study of photoinduced surface-relief-gratings on azo polymer and azo molecular glass films.RSC advances · 2021Article
- Directional mass transfer of azo molecular glass microsphere induced by polarized light in aqueous immersion media.RSC advances · 2021Article
- Transduction of cell and matrix geometric cues by the actin cytoskeleton.Current opinion in cell biology · 2021Review
- Multifunctional Structured Platforms: From Patterning of Polymer-Based Films to Their Subsequent Filling with Various Nanomaterials.Polymers · 2021Review
- Recent Development of Photodeformable Crystals: From Materials to Mechanisms.Research (Washington, D.C.) · 2021Review
- Dynamic azopolymeric interfaces for photoactive cell instruction.Biophysics reviews · 2020Review
- Quantitative Study of Morphological Features of Stem Cells onto Photopatterned Azopolymer Films.Journal of functional biomaterials · 2020Article
- Driving Cells with Light-Controlled Topographies.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cell-substrate interactions can modulate cellular behaviors in a variety of biological contexts, including development and disease. Light-responsive materials have been recently proposed to engineer active substrates with programmable topographies directing cell adhesion, migration, and differentiation. However, current approaches are affected by either fabrication complexity, limitations in the extent of mechanical stimuli, lack of full spatio-temporal control, or ease of use. Here, a platform exploiting light to plastically deform micropatterned polymeric substrates is presented. Topographic changes with remarkable relief depths in the micron range are induced in parallel, by illuminating the sample at once, without using raster scanners. In few tens of seconds, complex topographies are instructed on demand, with arbitrary spatial distributions over a wide range of spatial and temporal scales. Proof-of-concept data on breast cancer cells and normal kidney epithelial cells are presented. Both cell types adhere and proliferate on substrates without appreciable cell damage upon light-induced substrate deformations. User-provided mechanical stimulation aligns and guides cancer cells along the local deformation direction and constrains epithelial colony growth by biasing cell division orientation. This approach is easy to implement on general-purpose optical microscopy systems and suitable for use in cell biology in a wide variety of applications.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.