Evidence map›Paper›PMID 31379943›Full record

ArticleJournal of oncology2019

CD133 Is Associated with Increased Melanoma Cell Survival after Multikinase Inhibition.

Cynthia M Simbulan-Rosenthal, Anirudh Gaur, Hengbo Zhou, Maryam AbdusSamad, Qing Qin, Ryan Dougherty, Leala Aljehane, Li-Wei Kuo, Sahar Vakili, Kumari Karna and 3 more

Open access · hybridAbstract read
In one paragraph

Article in Journal of oncology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.3field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 21 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Cynthia M Simbulan-RosenthalDepartment of Biochemistry and Molecular Biology, Georgetown University School of Medicine, Washington, DC 20007, USA.
Anirudh GaurDepartment of Biochemistry and Molecular Biology, Georgetown University School of Medicine, Washington, DC 20007, USA.
Hengbo ZhouDepartment of Biochemistry and Molecular Biology, Georgetown University School of Medicine, Washington, DC 20007, USA.
Maryam AbdusSamadDepartment of Biochemistry and Molecular Biology, Georgetown University School of Medicine, Washington, DC 20007, USA.
Qing QinDepartment of Biochemistry and Molecular Biology, Georgetown University School of Medicine, Washington, DC 20007, USA.
Ryan DoughertyDepartment of Biochemistry and Molecular Biology, Georgetown University School of Medicine, Washington, DC 20007, USA.ORCID https://orcid.org/0000-0002-0330-0119
Leala AljehaneDepartment of Biochemistry and Molecular Biology, Georgetown University School of Medicine, Washington, DC 20007, USA.
Li-Wei KuoDepartment of Biochemistry and Molecular Biology, Georgetown University School of Medicine, Washington, DC 20007, USA.
Sahar VakiliDepartment of Biochemistry and Molecular Biology, Georgetown University School of Medicine, Washington, DC 20007, USA.ORCID https://orcid.org/0000-0003-1892-3236
Kumari KarnaDepartment of Biochemistry and Molecular Biology, Georgetown University School of Medicine, Washington, DC 20007, USA.
Havens ClarkDepartment of Biochemistry and Molecular Biology, Georgetown University School of Medicine, Washington, DC 20007, USA.
Edward McCarronDivision of Surgical Oncology, Harry and Jeanette Weinberg Cancer Institute, MedStar Franklin Square Medical Center, Rosedale, MD, USA.
Dean S RosenthalDepartment of Biochemistry and Molecular Biology, Georgetown University School of Medicine, Washington, DC 20007, USA.ORCID https://orcid.org/0000-0002-7624-0209
Georgetown University · USMedStar Franklin Square Medical Center · US

Funding

Immuno-CometChip for Human Skin Basal Cell Genotoxicity TestingR42ES026908 · NIEHS · AMELIA TECHNOLOGIES, LLC · PI GEORGE, JAY, ROSENTHAL, DEAN · 2018 to 2019
$1.5M
NIEHS NIH HHS R42 ES026908
6 · The paper itself

Abstract

FDA-approved kinase inhibitors are now used for melanoma, including combinations of the MEK inhibitor trametinib, and BRAF inhibitor dabrafenib for BRAFV600 mutations. NRAS-mutated cell lines are also sensitive to MEK inhibition

Identifiers

PMID31379943
PMCPMC6662463
OpenAlexW2962394345

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.