Evidence map›Paper›PMID 31379879›Full record

ReviewFrontiers in immunology2019

The Role of Inflammation in Depression and Fatigue.

Chieh-Hsin Lee, Fabrizio Giuliani

Registry-linked trialOpen access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05808101 (Role of the Gut Microbiome as Determinant of Depression in Multiple Sclerosis Subjects), which is not on this map. Cited by 315 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
315citing papers in PubMed, 9 pooled it
18.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05808101 terminatednot on this mapstarted 2022, after this paper: background citation

Role of the Gut Microbiome as Determinant of Depression in Multiple Sclerosis Subjects

TypeobservationalSponsorWashington University School of MedicineRan2022 to 2024Enrolled51ConditionsMultiple Sclerosis, DepressionArmsNeuro-QoL T-score determination
3 · Its place in the literature

Who cites it

315 citing papers in PubMed, 9 syntheses or guidelines pooled it, 626 citations in OpenAlex.

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255 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Chieh-Hsin LeeNeuroscience and Mental Health Institute, University of Alberta, Edmonton, AB, Canada.
Fabrizio GiulianiNeuroscience and Mental Health Institute, University of Alberta, Edmonton, AB, Canada.
Women and Children’s Health Research Institute · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Depression and fatigue are conditions responsible for heavy global societal burden, especially in patients already suffering from chronic diseases. These symptoms have been identified by those affected as some of the most disabling symptoms which affect the quality of life and productivity of the individual. While many factors play a role in the development of depression and fatigue, both have been associated with increased inflammatory activation of the immune system affecting both the periphery and the central nervous system (CNS). This is further supported by the well-described association between diseases that involve immune activation and these symptoms in autoimmune disorders, such as multiple sclerosis and immune system activation in response to infections, like sepsis. Treatments for depression also support this immunopsychiatric link. Antidepressants have been shown to decrease inflammation, while higher levels of baseline inflammation predict lower treatment efficacy for most treatments. Those patients with higher initial immune activation may on the other hand be more responsive to treatments targeting immune pathways, which have been found to be effective in treating depression and fatigue in some cases. These results show strong support for the hypothesis that depression and fatigue are associated with an increased activation of the immune system which may serve as a valid target for treatment. Further studies should focus on the pathways involved in these symptoms and the development of treatments that target those pathways will help us to better understand these conditions and devise more targeted treatments.

Indexed as

AnimalsAntidepressive AgentsDepressionFatigueHumansImmunologic FactorsInflammationAntidepressive AgentsImmunologic Factorsautoimmune diseasesdepressionfatigueinflammationpsychoneuroimmunology

Identifiers

PMID31379879
PMCPMC6658985
OpenAlexW2961101336

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.