Evidence map›Paper›PMID 31379863›Full record

ArticleFrontiers in immunology2019

Reduced Function and Diversity of T Cell Repertoire and Distinct Clinical Course in Patients With

Atar Lev, Amos J Simon, Ortal Barel, Eran Eyal, Efrat Glick-Saar, Omri Nayshool, Ohad Birk, Tali Stauber, Amit Hochberg, Arnon Broides and 4 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
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  9. A Spot of Good News: Israeli Experience With SCID Newborn Screening.The journal of allergy and clinical immunology. In practice · 2022
    Article
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  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 7 institutions in 1 country.

Atar LevThe National Lab for Diagnosing SCID - The Israeli Newborn Screening Program, Pediatric Department A and the Immunology Service, Jeffrey Modell Foundation Center, Sheba Medical Center, Edmond and Lily Safra Children's Hospital, Israel Ministry of Health, Tel HaShomer, Israel.
Amos J SimonSheba Cancer Research Center and Institute of Hematology, Sheba Medical Center, Tel HaShomer, Israel.
Ortal BarelSheba Cancer Research Center and Institute of Hematology, Sheba Medical Center, Tel HaShomer, Israel.
Eran EyalSheba Cancer Research Center and Institute of Hematology, Sheba Medical Center, Tel HaShomer, Israel.
Efrat Glick-SaarSheba Cancer Research Center and Institute of Hematology, Sheba Medical Center, Tel HaShomer, Israel.
Omri NayshoolSheba Cancer Research Center and Institute of Hematology, Sheba Medical Center, Tel HaShomer, Israel.
Ohad BirkSoroka Medical Center, Genetics Institute, The National Institute for Biotechnology in the Negev, Ben-Gurion University of the Negev, Beer Sheva, Israel.
Tali StauberThe National Lab for Diagnosing SCID - The Israeli Newborn Screening Program, Pediatric Department A and the Immunology Service, Jeffrey Modell Foundation Center, Sheba Medical Center, Edmond and Lily Safra Children's Hospital, Israel Ministry of Health, Tel HaShomer, Israel.
Amit HochbergDepartment of Pediatrics, Hillel Yaffe Medical Center, Hadera, Israel.
Arnon BroidesFaculty of Health Sciences, Soroka University Medical Center, Pediatric Immunology Clinic, Ben-Gurion University of the Negev, Beer Sheva, Israel.
Shlomo AlmashanuThe National Center for Newborn Screening, Israel Ministry of Health, Tel HaShomer, Israel.
Ayal HendelThe Mina and Everard Goodman Faculty of Life Sciences, Advanced Materials and Nanotechnology Institute, Bar-Ilan University, Ramat-Gan, Israel.
Yu Nee LeeThe National Lab for Diagnosing SCID - The Israeli Newborn Screening Program, Pediatric Department A and the Immunology Service, Jeffrey Modell Foundation Center, Sheba Medical Center, Edmond and Lily Safra Children's Hospital, Israel Ministry of Health, Tel HaShomer, Israel.
Raz SomechThe National Lab for Diagnosing SCID - The Israeli Newborn Screening Program, Pediatric Department A and the Immunology Service, Jeffrey Modell Foundation Center, Sheba Medical Center, Edmond and Lily Safra Children's Hospital, Israel Ministry of Health, Tel HaShomer, Israel.
Tel Aviv University · ILIsrael Ministry of Health · ILBen-Gurion University of the Negev · ILSheba Medical Center · ILBar-Ilan University · ILEdmond and Lily Safra Children's Hospital · ILHillel Yaffe Medical Center · IL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The alpha subunit of IL-7 receptor (IL7R7α) is critical for the differentiation of T cells, specifically for the development and maintenance of γδT cells. Mutations in

Indexed as

FemaleHumansImmune SystemInfant, NewbornInterleukin-7 Receptor alpha SubunitMaleMutationNeonatal ScreeningSevere Combined ImmunodeficiencySignal TransductionT-LymphocytesIL7R protein, humanInterleukin-7 Receptor alpha SubunitIIL7Rαimmune repertoireNBSPIDSCIDTREC

Identifiers

PMID31379863
PMCPMC6650764
OpenAlexW2953485956

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.