Evidence map›Paper›PMID 31379721›Full record

ReviewFrontiers in neurology2019

Prophylactic Treatment of Pediatric Migraine: Is There Anything New in the Last Decade?

Laura Papetti, Fabiana Ursitti, Romina Moavero, Michela Ada Noris Ferilli, Giorgia Sforza, Samuela Tarantino, Federico Vigevano, Massimiliano Valeriani

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in neurology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Trial
  5. Trial
  6. Trial
  7. Review
  8. Review
  9. Review
  10. Article
  11. Eyebrow bleeding as a rare migraine symptom: a case report.Annals of medicine and surgery (2012) · 2024
    Article
  12. Hallmarks of primary headache: part 1 - migraine.The journal of headache and pain · 2024
    Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Migraine, Allergy, and Histamine: Is There a Link?Journal of clinical medicine · 2023
    Review
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Laura PapettiDepartment of Neuroscience, Headache Center, Bambino Gesù Children Hospital, Rome, Italy.
Fabiana UrsittiDepartment of Neuroscience, Headache Center, Bambino Gesù Children Hospital, Rome, Italy.
Romina MoaveroDepartment of Neuroscience, Headache Center, Bambino Gesù Children Hospital, Rome, Italy.
Michela Ada Noris FerilliDepartment of Neuroscience, Headache Center, Bambino Gesù Children Hospital, Rome, Italy.
Giorgia SforzaChild Neurology Unit, Systems Medicine Department, Tor Vergata University Hospital of Rome, Rome, Italy.
Samuela TarantinoDepartment of Neuroscience, Headache Center, Bambino Gesù Children Hospital, Rome, Italy.
Federico VigevanoDepartment of Neuroscience, Headache Center, Bambino Gesù Children Hospital, Rome, Italy.
Massimiliano ValerianiDepartment of Neuroscience, Headache Center, Bambino Gesù Children Hospital, Rome, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Migraine is a frequent and very disabling disease, especially at pediatric age. Despite this, there are few controlled data on the prophylactic treatment of primary headaches in this category of age. Given that the recently introduced calcitonin gene-related peptide (CGRP) inhibitors (CGRP-r) are still limited to adulthood, there is no drug with exclusive indication for migraine treatment in pediatric age. This raises several limitations in terms of adherence and effectiveness of the therapy. Moreover, the scenario is complicated by placebo response, which is larger in children and adolescents than in adults and often leads to an improvement in the attack frequency even in absence of any active pharmacological treatment. Our aim was to investigate the real evidence concerning the prophylactic therapy of pediatric migraine by reviewing the clinical studies published between 2010 and 2019.

Indexed as

guidelinesmigrainepediatric migrainepreventiveprophylactic drugstherapytreatment

Identifiers

PMID31379721
PMCPMC6646427

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.