ArticleFrontiers in integrative neuroscience2019
Sensory Modulation Disorder (SMD) and Pain: A New Perspective.
Article in Frontiers in integrative neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 52 citations in OpenAlex.
- A Cross-Neurotype Analysis of Camouflaging and Illness Perceptions in People with Central Sensitivity Syndromes.Autism in adulthood · 2026Article
- Exploring central sensitization symptoms in children with ADHD and their parents: a case-control study.BMC psychiatry · 2026Article
- Group-Based Psychological Interventions for Autistic Youth with Chronic Pain: Narrative Review and Practice Considerations for Intensive Interdisciplinary Pediatric Pain Treatment.Journal of clinical psychology in medical settings · 2026Review
- Visual Hypersensitivity as a Transdiagnostic Marker of Surgical Pain Response in Arthritis and Chronic Pain Syndromes.Arthritis & rheumatology (Hoboken, N.J.) · 2026Article
- Difficulties in emotion regulation mediate the association between sensory over-responsiveness and motor coordination symptoms in community-dwelling midlife adults: a cross-sectional analysis.Frontiers in psychology · 2026Article
- Conditioned pain modulation, cortical imbalance, and arthrogenic muscle inhibition: an integrative model with implications for exercise in chronic pain.Frontiers in pain research (Lausanne, Switzerland) · 2026Review
- Sensory modulation difficulties and complex PTSD among child abuse survivors.European journal of psychotraumatology · 2025Article
- Multimodal hypersensitivity and somatic symptoms predict adolescent postmenarchal widespread pain.Pain · 2025Article
- Sensory Processing Patterns in People With Complex Regional Pain Syndrome.OTJR : occupation, participation and health · 2025Article
- Patient subtyping in juvenile fibromyalgia: the role of multisensory hypersensitivity and neurophysiological correlates.Journal of pediatric psychology · 2025Article
- Low sensory responsiveness is associated with accelerated aging in midlife.Scientific reports · 2025Article
- Thalamic CGRP neurons define a spinothalamic pathway for affective pain.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Central Sensitivity Symptoms and Autistic Traits in Autistic and Non-Autistic Adults.Autism research : official journal of the International Society for Autism Research · 2025Article
- Chronic sleep deficiency and its impact on pain perception in healthy females.Journal of sleep research · 2025Article
- Effects of warm silver needle acupuncture combined with myofascial trigger point intervention on peripheral neutrophil autophagy and alleviation of chronic pelvic pain in women.American journal of translational research · 2025Article
- Multisensory sensitivity in relation to pain: a scoping review of terminology and assessment.Pain reports · 2024Article
- The Functional-Cognitive and Sensory Treatment (F-CaST) to improve rehabilitation outcomes of individuals with substance use disorder: a study protocol for a mixed-method randomized controlled trial.Addiction science & clinical practice · 2024Article
- Attenuation of Streptozotocin-Induced Diabetic Neuropathic Allodynia by Flavone Derivative Through Modulation of GABA-ergic Mechanisms and Endogenous Biomarkers.Neurochemical research · 2024Article
- Measuring habituation to stimuli: The Italian version of the Sensory Habituation Questionnaire.PloS one · 2024Article
- Pain sensitivity and perceptual sensitivity are associated with severity of emotional dysregulation in children with ADHD: a cross-sectional analysis using the Temperament in Middle Childhood Questionnaire.Disability and rehabilitation · 2023Article
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Authors and funding
4 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sensory modulation disorder (SMD) affects sensory processing across single or multiple sensory systems. The sensory over-responsivity (SOR) subtype of SMD is manifested clinically as a condition in which non-painful stimuli are perceived as abnormally irritating, unpleasant, or even painful. Moreover, SOR interferes with participation in daily routines and activities (Dunn, 2007; Bar-Shalita et al., 2008; Chien et al., 2016), co-occurs with daily pain hyper-sensitivity, and reduces quality of life due to bodily pain. Laboratory behavioral studies have confirmed abnormal pain perception, as demonstrated by hyperalgesia and an enhanced lingering painful sensation, in children and adults with SMD. Advanced quantitative sensory testing (QST) has revealed the mechanisms of altered pain processing in SOR whereby despite the existence of normal peripheral sensory processing, there is enhanced facilitation of pain-transmitting pathways along with preserved but delayed inhibitory pain modulation. These findings point to central nervous system (CNS) involvement as the underlying mechanism of pain hypersensitivity in SOR. Based on the mutual central processing of both non-painful and painful sensory stimuli, we suggest shared mechanisms such as cortical hyper-excitation, an excitatory-inhibitory neuronal imbalance, and sensory modulation alterations. This is supported by novel findings indicating that SOR is a risk factor and comorbidity of chronic non-neuropathic pain disorders. This is the first review to summarize current empirical knowledge investigating SMD and pain, a sensory modality not yet part of the official SMD realm. We propose a neurophysiological mechanism-based model for the interrelation between pain and SMD. Embracing the pain domain could significantly contribute to the understanding of this condition's pathogenesis and how it manifests in daily life, as well as suggesting the basis for future potential mechanism-based therapies.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.