ArticleFrontiers in cellular neuroscience2019
Enriched Environment Shortens the Duration of Action Potentials in Cerebellar Granule Cells.
Article in Frontiers in cellular neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 17 citations in OpenAlex.
- Unreliable homeostatic action potential broadening in cultured dissociated neurons.bioRxiv : the preprint server for biology · 2025Article
- Environmental Enrichment Enhances Cerebellar Compensation and Develops Cerebellar Reserve.International journal of environmental research and public health · 2022Review
- Computational models of neurotransmission at cerebellar synapses unveil the impact on network computation.Frontiers in computational neuroscience · 2022Review
- New prospects on cerebellar reserve: Remarks on neuroprotective effects of experience in animals and humans.Frontiers in systems neuroscience · 2022Review
- Environmental enrichment reverses cerebellar impairments caused by prenatal exposure to a synthetic glucocorticoid.AIMS neuroscience · 2022Article
- Developmental and activity-dependent modulation of coupling distance between release site and CaFrontiers in cellular neuroscience · 2022Review
- Resurgent NaNature communications · 2021Article
- Two-Photon Laser Ablation and In Vivo Wide-Field Imaging of Inferior Olive Neurons Revealed the Recovery of Olivocerebellar Circuits in Zebrafish.International journal of environmental research and public health · 2021Article
- Environmental Enrichment Improves Vestibular Oculomotor Learning in Mice.Frontiers in behavioral neuroscience · 2021Article
- Loss of Piccolo Function in Rats Induces Cerebellar Network Dysfunction and Pontocerebellar Hypoplasia Type 3-like Phenotypes.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Environmental enrichment for rodents is known to enhance motor performance. Structural and molecular changes have been reported to be coupled with an enriched environment, but functional alterations of single neurons remain elusive. Here, we compared mice raised under control conditions and an enriched environment. We tested the motor performance on a rotarod and subsequently performed whole-cell patch-clamp recordings in cerebellar slices focusing on granule cells of lobule IX, which is known to receive vestibular input. Mice raised in an enriched environment were able to remain on an accelerating rotarod for a longer period of time. Electrophysiological analyses revealed normal passive properties of granule cells and a functional adaptation to the enriched environment, manifested in faster action potentials (APs) with a higher depolarized voltage threshold and larger AP overshoot. Furthermore, the maximal firing frequency of APs was higher in mice raised in an enriched environment. These data show that enriched environment causes specific alterations in the biophysical properties of neurons. Furthermore, we speculate that the ability of cerebellar granule cells to generate higher firing frequencies improves motor performance.
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