Evidence map›Paper›PMID 31379474›Full record

ArticleFrontiers in neuroscience2019

Genome-Wide DNA Methylation Analysis Reveals Epigenetic Pattern of

Shuang Liang, Zhenzhi Li, Yihan Wang, Xiaodan Li, Xiaolei Yang, Xiaolei Zhan, Yan Huang, Zhaomin Gao, Min Zhang, Caihong Sun and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
2.4field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Review
  5. Article
  6. Article
  7. Review
  8. Article
  9. The association betweenFrontiers in behavioral neuroscience · 2022
    Article
  10. Article
  11. Article
  12. Article
  13. The Epigenome in Neurodevelopmental Disorders.Frontiers in neuroscience · 2021
    Review
  14. Article
  15. Review
  16. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 2 countries.

Shuang LiangDepartment of Child and Adolescent Health, School of Public Health, Harbin Medical University, Harbin, China.
Zhenzhi LiDepartment of Biochemistry and Molecular & Cellular Biology, Georgetown University Medical Center, Washington, DC, United States.
Yihan WangCollege of Bioinformatics Science and Technology, Harbin Medical University, Harbin, China.
Xiaodan LiDepartment of Child and Adolescent Health, School of Public Health, Harbin Medical University, Harbin, China.
Xiaolei YangDepartment of Child and Adolescent Health, School of Public Health, Harbin Medical University, Harbin, China.
Xiaolei ZhanDepartment of Child and Adolescent Health, School of Public Health, Harbin Medical University, Harbin, China.
Yan HuangDepartment of Child and Adolescent Health, School of Public Health, Harbin Medical University, Harbin, China.
Zhaomin GaoDepartment of Child and Adolescent Health, School of Public Health, Harbin Medical University, Harbin, China.
Min ZhangCollege of Bioinformatics Science and Technology, Harbin Medical University, Harbin, China.
Caihong SunDepartment of Child and Adolescent Health, School of Public Health, Harbin Medical University, Harbin, China.
Yan ZhangCollege of Bioinformatics Science and Technology, Harbin Medical University, Harbin, China.
Lijie WuDepartment of Child and Adolescent Health, School of Public Health, Harbin Medical University, Harbin, China.
Harbin Medical University · CNGeorgetown University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder. Aberrant DNA methylation has been observed in ASD but the mechanisms remain largely unknown. Here, we employed discordant monozygotic twins to investigate the contribution of DNA methylation to ASD etiology. Genome-wide DNA methylation analysis was performed using samples obtained from five pairs of ASD-discordant monozygotic twins, which revealed a total of 2,397 differentially methylated genes. Further, such gene list was annotated with Kyoto Encyclopedia of Genes and Genomes and demonstrated predominant activation of neurotrophin signaling pathway in ASD-discordant monozygotic twins. The methylation of

Indexed as

autism spectrum disorderdiscordantDNA methylationmonozygotic twinsSH2B1

Identifiers

PMID31379474
PMCPMC6660254
OpenAlexW2957622120

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.