ArticleJournal of the American Heart Association2019
Subclinical Longitudinal Change in Ankle-Brachial Index With Aging in a Community-Dwelling Population Is Associated With Central Arterial Stiffening.
Article in Journal of the American Heart Association, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 21 citations in OpenAlex.
- Clinical effects of Yiqi-Yangyin-Huoxue granules in the management of type 2 diabetes mellitus and early vascular aging: a randomized, double-blind, placebo-controlled trial protocol.Frontiers in medicine · 2026Article
- Ankle-brachial index trajectory before death in patients receiving maintenance hemodialysis.Clinical and experimental nephrology · 2025Article
- Relationship between ankle brachial index and carotid-femoral pulse wave velocity in hypertension patients with diabetes mellitus.International journal of cardiology. Heart & vasculature · 2025Article
- Arterial stiffness in people with HIV: a cross-sectional, comparative study with echocardiographic outcomes in Tanzania.AIDS (London, England) · 2025Article
- Reduced oxidative capacity of skeletal muscle mitochondria IS a fundamental consequence of adult ageing.The Journal of physiology · 2025Article
- Longitudinal decline in peak V̇oAmerican journal of physiology. Heart and circulatory physiology · 2024Article
- Arterial stiffness index, physical activity and food and nutrient intake: cross-sectional study in adults aged 40 years and older.Korean journal of community nutrition · 2024Article
- Preclinical systolic dysfunction relating to ankle-brachial index among high-risk PAD population with preserved left ventricular ejection fraction.Scientific reports · 2024Article
- Vascular ageing: moving from bench towards bedside.European journal of preventive cardiology · 2023Article
- Paradox of the Relationship between Cardio-Ankle Vascular Index and Ankle-Brachial Index in Patients with Lower Extremity Artery Disease.Annals of vascular diseases · 2023Article
- Ankle-Brachial Index and Energy Production in People Without Peripheral Artery Disease: The BLSA.Journal of the American Heart Association · 2022Article
- Longitudinal Changes in Resting Metabolic Rates with Aging Are Accelerated by Diseases.Nutrients · 2020Article
- Cellular Senescence in Arterial Diseases.Journal of lipid and atherosclerosis · 2020Review
- Subclinical Longitudinal Change in Ankle-Brachial Index With Aging in a Community-Dwelling Population Is Associated With Central Arterial Stiffening.Journal of the American Heart Association · 2019Article
- Relationships between Cardio-Ankle Vascular Index and Peptides Related to Hypertensive Disorders of Pregnancy in Patients with Lower Extremity Arterial Disease.Pulse (Basel, Switzerland)Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Background Aging is associated with a modest decline in ankle-brachial index (ABI); however, the underpinnings of this decline are not fully understood. The greater systolic ankle than brachial blood pressure, a normal ABI implies, is partially attributed to lower central than peripheral arterial stiffness. Hence, we examined the hypothesis that the age-associated decline in ABI is associated with central arterial stiffening with aging, assessed by pulse wave velocity. Methods and Results We analyzed longitudinal data from 974 participants aged 27 to 95 years from the Baltimore Longitudinal Study of Aging who were free of clinically significant cardiovascular disease. Participants had an average of 4 visits with a 6.8-year average follow-up time. Linear mixed-effects models showed that the average ABI decline beyond the age of 70 years was 0.03 per decade. In multiple regression analysis, the ABI rate of change was inversely associated with initial age (standardized β=-0.0711, P=0.0282), independent of peripheral disease factors and baseline ABI. After adjustment, the pulse wave velocity rate of change was inversely associated with ABI rate of change (standardized β=-0.0993, P=0.0040), rendering the association of the latter with initial age nonsignificant (standardized β=-0.0265, P=0.5418). Conclusions A modest longitudinal decline in ABI beyond the age of 70 years was shown to be independent of traditional risk factors for peripheral arterial disease but was accounted for by an increase in pulse wave velocity. A modest decline in ABI with aging might be a manifestation of changes in central hemodynamics and not necessarily attributable to peripheral flow-limiting factors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.