ArticleJournal of the American Heart Association2019
Arterial Stiffness Can Be Modulated by Pressure-Independent Mechanisms in Hypertension.
Article in Journal of the American Heart Association, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07768865 (Arterial Stiffness in Children and Young People With Hypertension and Chronic Kidney Disease), which is not on this map. Cited by 16 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Arterial Stiffness in Children and Young People With Hypertension and Chronic Kidney Disease
Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.
- Influence of Blood Pressure Reduction on Pulse Wave Velocity in Primary Hypertension: A Meta-Analysis and Comparison With an Acute Modulation of Transmural Pressure.Hypertension (Dallas, Tex. : 1979) · 2024Pooled it
- A randomised, factorial trial to reduce arterial stiffness independently of blood pressure: Proof of concept? The VaSera trial testing dietary nitrate and spironolactone.British journal of clinical pharmacology · 2020Trial
- Imeglimin Treatment May Improve Whole-Blood Fluidity and Influence Hemorheology in Patients with Type 2 Diabetes Mellitus: A Post Hoc Analysis of the INFINITY Study.Journal of personalized medicine · 2026Article
- Beat-to-beat variability of aortic pulse wave velocity: implications for aortic stiffness measurements.Journal of hypertension · 2025Article
- The association of structural versus load-dependent large artery stiffness mechanisms with cerebrovascular damage and cortical atrophy in humans.GeroScience · 2024Article
- Instability in Computational Models of Vascular Smooth Muscle Cell Contraction.Annals of biomedical engineering · 2024Article
- Can Pulse Rate Variability be Used to Monitor Compliance with a Breath Pacer?Applied psychophysiology and biofeedback · 2024Article
- Association Between Arterial Stiffness and Measures of Autonomic Dysfunction in People With Chronic Kidney Disease.Canadian journal of kidney health and disease · 2023Article
- Simple Models of Complex Mechanics for Improved Hypertension Care: Learning to De-stiffen Arteries.Artery research · 2023Review
- Effects of nitroglycerin-induced vasodilation on elastic and muscular artery stiffness in older Veterans.Hypertension research : official journal of the Japanese Society of Hypertension · 2022Article
- Clinical Relevance of the Sympathetic-Vascular Interactions in Health and Disease.Biomedicines · 2021Review
- The physiological effects of cardiac resynchronization therapy on aortic and pulmonary flow and dynamic and static components of systemic impedance.Heart rhythm O2 · 2021Article
- Mutation of the 5'-untranslated region stem-loop mRNA structure reduces type I collagen deposition and arterial stiffness in male obese mice.American journal of physiology. Heart and circulatory physiology · 2021Article
- Wearable Cuff-Less Blood Pressure Estimation at Home via Pulse Transit Time.IEEE journal of biomedical and health informatics · 2021Article
- Prolonged Elevation of Arterial Stiffness Following Peak Aerobic Exercise in Individuals With Chronic Stroke.Frontiers in physiology · 2021Article
- Arterial Stiffness Can Be Modulated by Pressure-Independent Mechanisms in Hypertension.Journal of the American Heart Association · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Background Effects of short-term interventions on large-artery stiffness assessed by pulse wave velocity (PWV) have mainly been explained by concomitant changes in blood pressure (BP). However, lower body negative pressure, which increases sympathetic activity and has other hemodynamic effects, has a specific effect on PWV in healthy volunteers. Methods and Results We examined effects of lower-limb venous occlusion (LVO), a similar intervention to lower-body negative pressure that reduces BP but increases sympathetic activity and device-guided breathing (DGB), which reduces both BP and sympathetic activity, on PWV in patients with essential hypertension (n=70 after LVO, n=45 after DGB and LVO in random order). The short-acting calcium channel antagonist nifedipine was used as a control for changes in BP. LVO produced a small but significant reduction in mean arterial pressure of 1.8 (95% CI 0.3-3.4) mm Hg. Despite this, aortic and carotid-femoral PWV increased during LVO by 0.8 (0.2-1.4) m/s and 0.7 (0.3-1.05) m/s, respectively. DGB reduced PWV by 1.2 (0.9-1.4) m/s, to a greater extent than did nifedipine 10 mg (reduction of 0.7 [0.1-1.3] m/s, P<0.05 compared with reduction during DGB). This occurred despite a greater decrease in BP with nifedipine compared with DGB. Conclusions Arterial stiffness can be modulated independently of BP over the short term. The mechanism could involve alterations in sympathetic activity or other as yet uncharacterized effects of LVO and DGB.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.