ArticleEMBO reports2019
Cerebrovascular endothelial cells form transient Notch-dependent cystic structures in zebrafish.
Article in EMBO reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 19 citations in OpenAlex.
- Light-sheets and smart microscopy, an exciting future is dawning.Communications biology · 2023Review
- Therapeutic targeting of vascular malformation in a zebrafish model of hereditary haemorrhagic telangiectasia.Disease models & mechanisms · 2023Article
- Actin cytoskeleton in angiogenesis.Biology open · 2022Review
- Analysis of the H-Ras mobility pattern in vivo shows cellular heterogeneity inside epidermal tissue.Disease models & mechanisms · 2022Article
- Zebrafish vascular quantification: a tool for quantification of three-dimensional zebrafish cerebrovascular architecture by automated image analysis.Development (Cambridge, England) · 2022Article
- Cerebrovascular development: mechanisms and experimental approaches.Cellular and molecular life sciences : CMLS · 2021Review
- Quantifying endothelial cell proliferation in the zebrafish embryo.F1000Research · 2021Article
- Established, New and Emerging Concepts in Brain Vascular Development.Frontiers in physiology · 2021Review
- The effect of absent blood flow on the zebrafish cerebral and trunk vasculature.Vascular biology (Bristol, England) · 2021Article
- Endothelial Cell Dynamics in Vascular Development: Insights From Live-Imaging in Zebrafish.Frontiers in physiology · 2020Review
- Cerebrovascular endothelial cells form transient Notch-dependent cystic structures in zebrafish.EMBO reports · 2019Article
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Authors and funding
13 authors at 3 institutions in 3 countries.
Funding
Abstract
We identify a novel endothelial membrane behaviour in transgenic zebrafish. Cerebral blood vessels extrude large transient spherical structures that persist for an average of 23 min before regressing into the parent vessel. We term these structures "kugeln", after the German for sphere. Kugeln are only observed arising from the cerebral vessels and are present as late as 28 days post fertilization. Kugeln do not communicate with the vessel lumen and can form in the absence of blood flow. They contain little or no cytoplasm, but the majority are highly positive for nitric oxide reactivity. Kugeln do not interact with brain lymphatic endothelial cells (BLECs) and can form in their absence, nor do they perform a scavenging role or interact with macrophages. Inhibition of actin polymerization, Myosin II, or Notch signalling reduces kugel formation, while inhibition of VEGF or Wnt dysregulation (either inhibition or activation) increases kugel formation. Kugeln represent a novel Notch-dependent NO-containing endothelial organelle restricted to the cerebral vessels, of currently unknown function.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.