Evidence map›Paper›PMID 31379000›Full record

ArticleAmerican journal of hematology2019

Predicting venous thromboembolism in multiple myeloma: development and validation of the IMPEDE VTE score.

Kristen M Sanfilippo, Suhong Luo, Tzu-Fei Wang, Mark Fiala, Martin Schoen, Tanya M Wildes, Joseph Mikhael, Nicole M Kuderer, David C Calverley, Jesse Keller and 3 more

Open access · greenAbstract readValidation Study
In one paragraph

Article in American journal of hematology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 89 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
89citing papers in PubMed, 3 pooled it
14.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

89 citing papers in PubMed, 3 syntheses or guidelines pooled it, 170 citations in OpenAlex.

  1. Pooled it
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  13. Unmet Needs and Challenges in Cancer-Associated Venous Thromboembolism.International journal of molecular sciences · 2026
    Review
  14. Article
  15. Article
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  18. Anticoagulants in hematologic malignancies: what is the data?Hematology. American Society of Hematology. Education Program · 2025
    Review
  19. Article
  20. Review

29 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 7 institutions in 1 country.

Kristen M SanfilippoDivision of Hematology/Oncology, Veterans Administration St. Louis Health Care System, St. Louis, Missouri.ORCID 0000-0002-0433-7845
Suhong LuoDivision of Hematology/Oncology, Veterans Administration St. Louis Health Care System, St. Louis, Missouri.
Tzu-Fei WangDivision of Hematology, The Ohio State University Comprehensive Cancer Center, Columbus, Ohio.
Mark FialaDivision of Oncology, Washington University School of Medicine Saint Louis, St. Louis, Missouri.
Martin SchoenDivision of Hematology/Oncology, Saint Louis University, St. Louis, Missouri.
Tanya M WildesDivision of Oncology, Washington University School of Medicine Saint Louis, St. Louis, Missouri.ORCID 0000-0002-1479-7626
Joseph MikhaelApplied Cancer Research and Drug Discovery,Translational Genomics Research Institute (TGen), City of Hope Cancer Center, Duarte, California.ORCID 0000-0001-9670-2864
Nicole M KudererAdvanced Cancer Research Group, University of Washington, Seattle, Washington.
David C CalverleyDivision of Hematology/Oncology, Veterans Administration Portland Health Care System, Portland, Oregon.
Jesse KellerDivision of Hematology/Oncology, Veterans Administration St. Louis Health Care System, St. Louis, Missouri.
Theodore ThomasDivision of Hematology/Oncology, Veterans Administration St. Louis Health Care System, St. Louis, Missouri.
Kenneth R CarsonDivision of Hematology/Oncology, Veterans Administration St. Louis Health Care System, St. Louis, Missouri.
Brian F GageDivision of General Medical Sciences, Washington University School of Medicine Saint Louis, St. Louis, Missouri.
Washington University in St. Louis · USVA St. Louis Health Care System · USSaint Louis University Hospital · USSeattle Cancer Care Alliance · USThe Ohio State University · USTranslational Genomics Research Institute · USVA Portland Health Care System · US

Funding

WU INSTITUTE OF CLINICAL AND TRANSLATIONAL SCIENCESUL1TR002345 · NCATS · WASHINGTON UNIVERSITY · PI William G. Powderly · 2017 to 2026
$97.8M
Washington University Institute of Clinical and Translational SciencesUL1TR000448 · NCATS · WASHINGTON UNIVERSITY · PI EVANOFF, BRADLEY A · 2012 to 2016
$41.4M
Washington University Paul Calabresi K12 Career Development Award for Clinical OncologyK12CA167540 · NCI · WASHINGTON UNIVERSITY · PI John F. Dipersio, Ramaswamy Govindan · 2012 to 2026
$11.7M
CLINICAL HEMATOLOGY RESEARCH CAREER DEVELOPMENT PROGRAM AT WASHINGTON UNIVERSITYK12HL087107 · NHLBI · WASHINGTON UNIVERSITY · PI SADLER, J EVAN · 2006 to 2016
$3.8M
WASHINGTON UNIVERSITY CER MENTORED CAREER DEVELOPMENT AWARD KM1KM1CA156708 · NCI · WASHINGTON UNIVERSITY · PI FRASER, VICTORIA J. · 2010 to 2010
$2.5M
WASHINGTON UNIVERSITY COMPARATIVE EFFECTIVENESS ADMINISTRATIVE DATA REPOSITORYR24HS019455 · AHRQ · WASHINGTON UNIVERSITY · PI FRASER, VICTORIA J. · 2010 to 2010
$969k
Prediction and Prevention of Venous Thromboembolism in Multiple MyelomaK01HL136893 · NHLBI · WASHINGTON UNIVERSITY · PI SANFILIPPO, KRISTEN MARIE · 2017 to 2019
$484k
AHRQ HHS R24 HS019455Centers for Medicare & Medicaid ServicesNCATS NIH HHS UL1 TR000448NCATS NIH HHS UL1 TR002345NCI NIH HHS K12 CA167540NCI NIH HHS KM1 CA156708NHLBI NIH HHS K01 HL136893NHLBI NIH HHS K12 HL087107
6 · The paper itself

Abstract

Venous thromboembolism (VTE) is a common cause of morbidity and mortality among patients with multiple myeloma (MM). The International Myeloma Working Group (IMWG) developed guidelines recommending primary thromboprophylaxis, in those identified at high-risk of VTE by the presence of risk factors. The National Comprehensive Cancer Network (NCCN) has adopted these guidelines; however, they lack validation. We sought to develop and validate a risk prediction score for VTE in MM and to evaluate the performance of the current IMWG/NCCN guidelines. Using 4446 patients within the Veterans Administration Central Cancer Registry, we used time-to-event analyses to develop a risk score for VTE in patients with newly diagnosed MM starting chemotherapy. We externally validated the score using the Surveillance, Epidemiology, End Results (SEER)-Medicare database (N = 4256). After identifying independent predictors of VTE, we combined the variables to develop the IMPEDE VTE score (Immunomodulatory agent; Body Mass Index ≥25 kg/m

Indexed as

AgedAnticoagulantsAntineoplastic Combined Chemotherapy ProtocolsBody Mass IndexCatheterization, Central VenousCombined Modality TherapyComorbidityDatabases, FactualDexamethasoneFemaleFollow-Up StudiesGlomerular Filtration RateHematopoietic Stem Cell TransplantationHumansMaleMedicareAnticoagulantsDexamethasone

Identifiers

PMID31379000
PMCPMC7058359
OpenAlexW2964490813

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.