ReviewSeminars in neurology2019
Diagnostic Testing in Central Nervous System Infection.
Review in Seminars in neurology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Bridging the diagnostic gap: the role of culture methods in the era of syndromic panels for central nervous system infections.Frontiers in cellular and infection microbiology · 2026Article
- Evaluating the Clinical Impact of Metagenomic Next-Generation Sequencing in CNS Infections: A Diagnostic Pathway and Resource Utilization Modeling Study.Open forum infectious diseases · 2026Article
- Unraveling the Burden of Viral and Bacterial Central Nervous System Infections: A Two-Year Retrospective Study.Diagnostics (Basel, Switzerland) · 2025Article
- Toxoplasma gondii infection diagnosed by tNGS in a patient with acute lymphoblastic leukemia: a case report.BMC infectious diseases · 2025Article
- Recent advances in diagnostic technologies for postoperative central nervous system infections: a review.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025Review
- What every neuropathologist needs to know: Update on neuro infectious disease workups and consultation resources.Journal of neuropathology and experimental neurology · 2025Review
- Time to Confirmed Neuroinfectious Diagnoses: Diagnostic Testing and Resource Allocation.The Neurohospitalist · 2024Article
- Review
- Case report: A toxoplasmic encephalitis in an immunocompromised child detected through metagenomic next-generation sequencing.Frontiers in public health · 2023Article
- Inconsistency analysis between metagenomic next-generation sequencing results of cerebrospinal fluid and clinical diagnosis with suspected central nervous system infection.BMC infectious diseases · 2022Article
- The clinical application of metagenomic next-generation sequencing in infectious diseases at a tertiary hospital in China.Frontiers in cellular and infection microbiology · 2022Observational
- Evaluation of vancomycin pharmacokinetics in patients with augmented renal clearances: A randomized clinical trial.Frontiers in pharmacology · 2022Article
- Trends and Developments in the Detection of Pathogens in Central Nervous System Infections: A Bibliometric Study.Frontiers in cellular and infection microbiology · 2022Article
- Value of lipocalin 2 as a potential biomarker for bacterial meningitis.Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases · 2020Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Patients with central nervous system (CNS) infection experience very high levels of morbidity and mortality, in part because of the many challenges inherent to the diagnosis of CNS infection and identification of a causative pathogen. The clinical presentation of CNS infection is nonspecific, so clinicians must often order and interpret many diagnostic tests in parallel. This can be a daunting task given the large number of potential pathogens and the availability of different testing modalities. Here, we review traditional diagnostic techniques including Gram stain and culture, serology, and polymerase chain reaction (PCR). We highlight which of these are recommended for the pathogens most commonly tested among U.S. patients with suspected CNS infection. Finally, we describe the newer broad-range diagnostic approaches, multiplex PCR and metagenomic sequencing, which are increasingly used in clinical practice.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.