Evidence map›Paper›PMID 31378847›Full record

SynthesisInfection2020

Treatment failure definitions for non-purulent skin and soft tissue infections: a systematic review.

Krishan Yadav, Avik Nath, Kathryn N Suh, Lindsey Sikora, Debra Eagles

Registry-linked trialAbstract readSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Infection, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04471246 (High-dose Cephalexin for Cellulitis), which is not on this map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04471246 phase4completednot on this mapstarted 2021, after this paper: background citation

High-dose Cephalexin for Cellulitis: A Pilot Randomized Controlled Trial

TypeinterventionalSponsorOttawa Hospital Research InstituteRan2021 to 2022Enrolled69ConditionsCellulitisArmsCephalexin, Cephalexin + placebo
3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Krishan YadavDepartment of Emergency Medicine, University of Ottawa, Ottawa, Canada. kyadav@toh.ca.ORCID http://orcid.org/0000-0002-1547-4634
Avik NathDepartment of Emergency Medicine, University of Ottawa, Ottawa, Canada.
Kathryn N SuhDivision of Infectious Diseases, Department of Medicine, University of Ottawa, Ottawa, Canada.
Lindsey SikoraHealth Sciences Library, University of Ottawa, Ottawa, Canada.
Debra EaglesDepartment of Emergency Medicine, University of Ottawa, Ottawa, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThere is currently no uniform definition for antimicrobial treatment failure for adults with non-purulent skin and soft tissue infections (SSTIs). The objective of this systematic review was to identify treatment failure definitions and their common components in the literature.

methodsFive electronic databases were searched from inception to March 2019. Two independent reviewers identified studies involving adults (age ≥ 18 years) with non-purulent SSTIs in which antimicrobial treatment failure was a defined outcome. There were no language restrictions. Only randomized trials or observational studies were included.

resultsAfter screening 4953 abstracts, 26 studies (N = 6629 patients) met full inclusion criteria. Reported treatment failure ranged from 0 to 29.5%. The most common definition components were hospital admission (78.9%), change in antibiotics (65.4%), and persistent or worsening signs and symptoms of infection (34.6%). Only one study listed specific criteria for persistent or worsening signs and symptoms of infection.

conclusionsFor studies involving non-purulent SSTIs, the outcome of treatment failure is inconsistently defined and reported failure rates are highly variable. This systematic review has highlighted the need for more robust treatment failure definitions for non-purulent SSTIs. Research should focus on the development of a uniform treatment failure definition that should be used in future studies.

Indexed as

Treatment FailureAdultAgedAged, 80 and overAnti-Infective AgentsHumansMiddle AgedSkin Diseases, InfectiousSoft Tissue InfectionsTerminology as TopicYoung AdultAnti-Infective AgentsCellulitisSoft tissue infectionsTreatment failure

Identifiers

PMID31378847

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.