Evidence map›Paper›PMID 31378671›Full record

ArticleStem cell reports2019

Long-Term Safety, Immunologic Response, and Imaging Outcomes following Neural Stem Cell Transplantation for Pelizaeus-Merzbacher Disease.

Nalin Gupta, Roland G Henry, Sang-Mo Kang, Jonathan Strober, Daniel A Lim, Tamara Ryan, Rachel Perry, Jody Farrell, Mary Ulman, Raja Rajalingam and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Stem cell reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed, 1 pooled it
3.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 1 synthesis or guideline pooled it, 51 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Stem cell and gene therapies for leukodystrophies.Molecular therapy. Methods & clinical development · 2025
    Review
  7. Review
  8. Article
  9. Review
  10. Remyelination in the Central Nervous System.Cold Spring Harbor perspectives in biology · 2024
    Review
  11. Review
  12. Review
  13. Review
  14. Article
  15. The Ties That Bind: Glial Transplantation in White Matter Ischemia and Vascular Dementia.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2023
    Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 2 countries.

Nalin GuptaDepartment of Neurological Surgery, University of California San Francisco, 550 16(th) Street, 4(th) Floor, San Francisco, CA 94143-0137, USA; Department of Pediatrics, University of California San Francisco, San Francisco, CA 94143, USA. Electronic address: nalin.gupta@ucsf.edu.
Roland G HenryDepartment of Neurology, University of California San Francisco, San Francisco, CA 94143, USA; Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA 94143, USA; Bioengineering Graduate Group, University of California San Francisco & Berkeley, San Francisco, CA 94143, USA.
Sang-Mo KangDivision of Transplantation, Department of Surgery, University of California San Francisco, San Francisco, CA 94143, USA.
Jonathan StroberDepartment of Neurology, University of California San Francisco, San Francisco, CA 94143, USA; Department of Pediatrics, University of California San Francisco, San Francisco, CA 94143, USA.
Daniel A LimDepartment of Neurological Surgery, University of California San Francisco, 550 16(th) Street, 4(th) Floor, San Francisco, CA 94143-0137, USA.
Tamara RyanFetal Treatment Center, University of California San Francisco, San Francisco, CA 94143, USA.
Rachel PerryFetal Treatment Center, University of California San Francisco, San Francisco, CA 94143, USA.
Jody FarrellFetal Treatment Center, University of California San Francisco, San Francisco, CA 94143, USA.
Mary UlmanDepartment of Pediatrics, University of California San Francisco, San Francisco, CA 94143, USA.
Raja RajalingamImmunogenetics and Transplantation Laboratory, Department of Surgery, University of California San Francisco, San Francisco, CA 94143, USA.
Allyson GageStemCells Inc., Newark, CA 94560, USA.
Stephen L HuhnStemCells Inc., Newark, CA 94560, USA.
A James BarkovichDepartment of Neurology, University of California San Francisco, San Francisco, CA 94143, USA; Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA 94143, USA; Department of Pediatrics, University of California San Francisco, San Francisco, CA 94143, USA.
David H RowitchDepartment of Neurological Surgery, University of California San Francisco, 550 16(th) Street, 4(th) Floor, San Francisco, CA 94143-0137, USA; Department of Pediatrics, University of California San Francisco, San Francisco, CA 94143, USA; Department of Paediatrics, University of Cambridge, Cambridge CB2 1TN, UK.
University of California, San Francisco · USApplied StemCell (United States) · US

Funding

Medical Research Council MC_PC_12009
6 · The paper itself

Abstract

Four boys with Pelizaeus-Merzbacher disease, an X-linked leukodystrophy, underwent transplantation with human allogeneic central nervous system stem cells (HuCNS-SC). Subsequently, all subjects were followed for an additional 4 years in this separate follow-up study to evaluate safety, neurologic function, magnetic resonance imaging (MRI) data, and immunologic response. The neurosurgical procedure, immunosuppression, and HuCNS-SC transplantation were well tolerated and all four subjects were alive at the conclusion of the study period. At year 2, all subjects exhibited diffusion MRI changes at the implantation sites as well as in more distant brain regions. There were persistent, increased signal changes in the three patients who were studied up to year 5. Two of four subjects developed donor-specific HLA alloantibodies, demonstrating that neural stem cells can elicit an immune response when injected into the CNS, and suggesting the importance of monitoring immunologic parameters and identifying markers of engraftment in future studies.

Indexed as

BrainChild, PreschoolFollow-Up StudiesHLA AntigensHumansInfantIsoantibodiesMagnetic Resonance ImagingMaleNeural Stem CellsPelizaeus-Merzbacher DiseaseSeverity of Illness IndexStem Cell TransplantationTransplantation, HomologousTreatment OutcomeHLA AntigensIsoantibodiesleukodystrophymyelinneural stem cellsneurodegenerative diseaseoligodendrocytepediatricPelizaeus-Merzbacher diseasetransplantation

Identifiers

PMID31378671
PMCPMC6700500
OpenAlexW2966779737

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.