ArticleCurrent biology : CB2019
Adaptation of Inhibition Mediates Retinal Sensitization.
Article in Current biology : CB, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed.
- Spatially local inhibition and synaptic plasticity together enable dynamic, context-dependent integration of parallel sensory pathways.Cell reports · 2026Article
- Spatially-local inhibition and synaptic plasticity together enable dynamic, context-dependent integration of parallel sensory pathways.bioRxiv : the preprint server for biology · 2025Article
- Short-term plasticity and context-dependent circuit function: Insights from retinal circuitry.Science advances · 2024Review
- Temporal pattern recognition in retinal ganglion cells is mediated by dynamical inhibitory synapses.Nature communications · 2024Article
- GABA receptors mediate adaptation and sensitization processes in mouse retinal ganglion cells.Cognitive neurodynamics · 2024Article
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- Calibrating Vision: Concepts and Questions.Vision research · 2022Review
- Opposite forms of adaptation in mouse visual cortex are controlled by distinct inhibitory microcircuits.Nature communications · 2022Article
- Retinal Processing: Insights from Mathematical Modelling.Journal of imaging · 2022Article
- How inhibitory neurons increase information transmission under threshold modulation.Cell reports · 2021Article
- Adjudicating Between Local and Global Architectures of Predictive Processing in the Subcortical Auditory Pathway.Frontiers in neural circuits · 2021Review
- Functional-pathway-dominant contrast adaptation and sensitization in mouse retinal ganglion cells.Cognitive neurodynamics · 2020Article
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- High Contrast Allows the Retina to Compute More Than Just Contrast.Frontiers in cellular neuroscience · 2020Article
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Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
In response to a changing sensory environment, sensory systems adjust their neural code for a number of purposes, including an enhanced sensitivity for novel stimuli, prediction of sensory features, and the maintenance of sensitivity. Retinal sensitization is a form of short-term plasticity that elevates local sensitivity following strong, local, visual stimulation and has been shown to create a prediction of the presence of a nearby localized object. The neural mechanism that generates this elevation in sensitivity remains unknown. Using simultaneous intracellular and multielectrode recording in the salamander retina, we show that a decrease in tonic amacrine transmission is necessary for and is correlated spatially and temporally with ganglion cell sensitization. Furthermore, introducing a decrease in amacrine transmission is sufficient to sensitize nearby ganglion cells. A computational model accounting for adaptive dynamics and nonlinear pathways confirms a decrease in steady inhibitory transmission can cause sensitization. Adaptation of inhibition enhances the sensitivity to the sensory feature conveyed by an inhibitory pathway, creating a prediction of future input.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.