ArticleAmerican journal of surgery2019
Chronic stress induces persistent low-grade inflammation.
Article in American journal of surgery, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
59 citing papers in PubMed, 88 citations in OpenAlex.
- From metabolic intermediary to neurotransmitter: purinergic signaling in neurophysiology and vulnerability of brain circuits.Bioscience reports · 2026Review
- Impact of early life stress on the immune response and bone regeneration after fracture.Bone reports · 2026Article
- Exploring Loneliness, Social Factors, and Clinical Correlates of C-reactive Protein in African American Breast Cancer Survivors.Journal of racial and ethnic health disparities · 2026Article
- Psychoneuroendocrine Associations with Momentary Pelvic Pain in Endometriosis.International journal of behavioral medicine · 2026Article
- Psychobiological mechanisms underlying the association between early life stress and depression in adolescence.Molecular psychiatry · 2026Review
- Psychological Stress and Male Infertility: Oxidative Stress as the Common Downstream Pathway.Biomedicines · 2026Review
- Multisystem pathology in chronic variable stress: gut-liver-brain axis disruption and the therapeutic promise of magnesium-L-theanine.Therapeutic advances in endocrinology and metabolism · 2026Review
- Human placental extract, melsmon, suppresses stress-induced neuroinflammation and peripheral inflammation in a mouse model of depression.Frontiers in pharmacology · 2026Article
- The application of a new type of intestinal diversion devices in Beagle dogs with intestinal transection injury and hemorrhagic shock.Frontiers in bioengineering and biotechnology · 2026Article
- Modulating Role of Resveratrol in Metabolic and Inflammatory Dysregulation Caused by Surgical and Psychoemotional Stress in Rats.Pathophysiology : the official journal of the International Society for Pathophysiology · 2025Article
- The Role of Marriage and Partnership in Caregiving: Links to the Hypothalamic-Pituitary-Adrenal Axis.Couple & family psychology · 2025Article
- Article
- Psychological stress and physiological outcomes: investigating the impact of attention biases and emotional regulation in Chinese military service members.BMC public health · 2025Article
- Chronic Stress Disrupts Immune and Endocrine Axis, Inducing Persistent Behavioral Impairments in Male Rats: In Silico and In Vivo Insights.Neurochemical research · 2025Article
- The multifaceted impact of stress on immune function.Molecular biology reports · 2025Review
- Cannabidiol Lipid Nanoparticles Stabilize Gut-Brain-Bone Axis Integrity and Enhance Neuroplasticity in Stressed Rats: A Comparison with Atomoxetine and Escitalopram.International journal of molecular sciences · 2025Article
- Article
- The Interplay of Chronic Stress and Cancer: Pathophysiology and Implications for Integrated Care.Cancer reports (Hoboken, N.J.) · 2025Review
- Acute Stress and Autoimmune Markers: Evaluating the Psychoneuroimmunology Axis in Firefighter Recruits.International journal of molecular sciences · 2025Article
- Chronic Stress-Associated Depressive Disorders: The Impact of HPA Axis Dysregulation and Neuroinflammation on the Hippocampus-A Mini Review.International journal of molecular sciences · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
introductionThis study sought to determine if the systemic cytokine profile of rodents subjected to chronic restraint stress leads to persistent low-grade inflammation.
methodsMale Sprague-Dawley rats were subjected to restraint stress for a total of seven or fourteen days. Urine norepinephrine (NE), plasma interleukin 6 (IL-6), tumor necrosis factor alpha (TNF-α), C-reactive protein (CRP) were assessed with ELISA. Liver expression of IL-6 and TNF-α were assessed with real time PCR.
resultsChronic stress at 7 and 14 days sequentially increased plasma acute phase reactants (NE, IL-6, TNF-α, and CRP), liver IL-6 expression, hematopoietic progenitor cell mobilization, and decreased erythroid progenitor colony growth. Weight gain was reduced by chronic stress compared to each models' naïve counterpart.
conclusionsCombining this model with trauma and sepsis models will allow evaluation of the contribution of persistent inflammation in disease progression and outcomes.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.