ArticleHypertension (Dallas, Tex. : 1979)2019
Distinct Dimensions of Kidney Health and Risk of Cardiovascular Disease, Heart Failure, and Mortality.
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Article in Hypertension (Dallas, Tex. : 1979), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
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27citing papers in PubMed, 1 pooled it
2.8field-weighted citation impact, top 9% of its field
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Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.
- Artificial intelligence in the risk prediction models of cardiovascular disease and development of an independent validation screening tool: a systematic review.BMC medicine · 2024Pooled it
- Association of Urine Biomarkers of Kidney Tubule Injury and Dysfunction With Frailty Index and Cognitive Function in Persons With CKD in SPRINT.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2021Trial
- Kidney function and markers of renal damage after renal denervation. Does method of measurement matter? The Reshape CV-Risk Study.Journal of clinical hypertension (Greenwich, Conn.) · 2021Trial
- Proximal tubule reabsorptive dysfunction and risk of cardiovascular death among community-living adults: the HUNT-3 cohort.European heart journal open · 2026Article
- Non-albumin proteinuria is associated with all-cause mortality in community-dwelling adults.Scientific reports · 2026Article
- Associations of Biomarkers of Kidney Tubule Health with Retinal Microvascular Signs: The Multi-Ethnic Study of Atherosclerosis.Kidney360 · 2025Article
- Defining Kidney Health Dimensions and Their Associations with Adverse Outcomes in Persons with Diabetes and CKD.Clinical journal of the American Society of Nephrology : CJASN · 2025Article
- Application of biomarkers in the diagnosis of kidney disease.Frontiers in medicine · 2025Review
- Associations of Urine Epidermal Growth Factor With Kidney and Cardiovascular Outcomes in Individuals With CKD in SPRINT.Kidney international reports · 2024Article
- Integrating multiple kidney function markers to predict all-cause and cardiovascular disease mortality: prospective analysis of 366 758 UK Biobank participants.Clinical kidney journal · 2024Article
- Urine Epidermal Growth Factor and Kidney Function Decline in Middle-Aged Adults.Kidney medicine · 2024Article
- Urine Biomarkers of Kidney Tubule Health and Risk of Incident CKD in Persons Without Diabetes: The ARIC, MESA, and REGARDS Studies.Kidney medicine · 2024Article
- Clusters of Body Fat and Nutritional Parameters are Strongly Associated with Diabetic Kidney Disease in Adults with Type 2 Diabetes.Diabetes therapy : research, treatment and education of diabetes and related disorders · 2024Article
- Structural equation modeling (SEM) of kidney function markers and longitudinal CVD risk assessment.PloS one · 2023Article
- Clinical Risk Factors For Kidney Tubule Biomarker Abnormalities Among Hypertensive Adults With Reduced eGFR in the SPRINT Trial.American journal of hypertension · 2022Article
- Joint effects of carotid plaques and renal impairment on the risk of cardiovascular disease and all-cause death in a community-based population: The Kailuan cohort study.Frontiers in cardiovascular medicine · 2022Article
- Emerging Roles of Sodium Glucose Cotransporter 2 (SGLT-2) Inhibitors in Diabetic Cardiovascular Diseases: Focusing on Immunity, Inflammation and Metabolism.Frontiers in pharmacology · 2022Review
- 1,25-dihydroxyvitamin D as Predictor of Renal Worsening Function in Chronic Kidney Disease. Results From the PASCaL-1,25D Study.Frontiers in medicine · 2022Article
- The Promise of Tubule Biomarkers in Kidney Disease: A Review.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2021Review
- Biomarkers of Kidney Tubule Health, CKD Progression, and Acute Kidney Injury in SPRINT (Systolic Blood Pressure Intervention Trial) Participants.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2021Observational
Corrections and comments
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Authors and funding
12 authors at 6 institutions in 1 country.
Alexandra K LeeFrom the Department of Medicine, University of California San Francisco (A.K.L., V.J., M.G.S.).
Ronit KatzDivision of Nephrology, University of Washington, Seattle (R.K.).
Vasantha JotwaniFrom the Department of Medicine, University of California San Francisco (A.K.L., V.J., M.G.S.).
Pranav S GarimellaDivision of Nephrology-Hypertension, University of California San Diego (P.S.G., J.H.I).
Walter T AmbrosiusDepartment of Biostatistics and Data Science, Wake Forest School of Medicine, Winston-Salem, NC (W.T.A.).
Alfred K CheungDivision of Nephrology (A.K.C., K.L.R.), University of Utah, Salt Lake City.
Lisa H GrenDivision of Public Health (L.H.G.), University of Utah, Salt Lake City.
Javier A NeyraDivision of Nephrology, University of Texas Southwestern, Dallas (J.A.N.).
Henry PunziPunzi Medical Center Carrollton, TX (H.P.).
Kalani L RaphaelDivision of Nephrology (A.K.C., K.L.R.), University of Utah, Salt Lake City.
Michael G ShlipakFrom the Department of Medicine, University of California San Francisco (A.K.L., V.J., M.G.S.).
Joachim H IxDivision of Nephrology-Hypertension, University of California San Diego (P.S.G., J.H.I).
University of California, San Francisco · USUniversity of Utah · USUniversity of California, San Diego · USThe University of Texas Southwestern Medical Center · USUniversity of Washington · USWake Forest University · US
Funding
INSTITUTIONAL CLINICAL AND TRANSLATIONAL SCIENCE AWARDUL1RR024134 · NCRR · UNIVERSITY OF PENNSYLVANIA · PI FITZGERALD, GARRET A · 2006 to 2011
$70.4MMichigan Institute for Clinical and Health Research (MICHR)UL1TR002240 · NCATS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI LUMENG, JULIE C, MASHOUR, GEORGE ALEXANDER · 2017 to 2022
$54.9MUniversity of Pittsburgh Clinical and Translational Science InstituteUL1TR000005 · NCATS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI REIS, STEVEN E · 2012 to 2015
$50.8MClinical and Translational Science Collaborative of ClevelandUL1TR000439 · NCATS · CASE WESTERN RESERVE UNIVERSITY · PI KONSTAN, MICHAEL W. · 2012 to 2016
$50.0MMichigan Institute for Clinical and Health Research (MCHR)UL1TR000433 · NCATS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MASHOUR, GEORGE ALEXANDER · 2012 to 2016
$49.9MThe Vanderbilt Institute for Clinical and Translational Research (VICTR)UL1TR000445 · NCATS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BERNARD, GORDON RAPHAEL · 2012 to 2016
$41.4MInstitutional Clinical and Translational Science AwardUL1TR000003 · NCATS · UNIVERSITY OF PENNSYLVANIA · PI FITZGERALD, GARRET A · 2012 to 2015
$38.9MClinical and Translational Science Collaborative of ClevelandUL1TR002548 · NCATS · CASE WESTERN RESERVE UNIVERSITY · PI MCCOMSEY, GRACE A · 2018 to 2022
$35.5MStrengthening Stakeholder Engagement in Human Research Protections.UL1TR002003 · NCATS · UNIVERSITY OF ILLINOIS AT CHICAGO · PI KARNIK, NIRANJAN SUBHASH, MERMELSTEIN, ROBIN J. · 2016 to 2024
$33.7MWake Forest Clinical and Translational Science AwardUL1TR001420 · NCATS · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI ARD, JAMY D, FOLEY, KRISTIE L · 2015 to 2023
$32.3MTufts Clinical and Translational Research InstituteUL1TR001064 · NCATS · TUFTS UNIVERSITY BOSTON · PI SELKER, HARRY P. · 2013 to 2017
$26.4MUniversity of Iowa Clinical and Translational Science Program (TL1)UL1RR025755 · NCRR · OHIO STATE UNIVERSITY · PI JACKSON, REBECCA D · 2008 to 2011
$26.3MNCATS NIH HHS UL1 TR000002NCATS NIH HHS UL1 TR000003NCATS NIH HHS UL1 TR000005NCATS NIH HHS UL1 TR000050NCATS NIH HHS UL1 TR000064NCATS NIH HHS UL1 TR000073NCATS NIH HHS UL1 TR000075NCATS NIH HHS UL1 TR000093NCATS NIH HHS UL1 TR000105NCATS NIH HHS UL1 TR000433NCATS NIH HHS UL1 TR000439NCATS NIH HHS UL1 TR000445NCATS NIH HHS UL1 TR001064NCATS NIH HHS UL1 TR001420NCATS NIH HHS UL1 TR002003NCATS NIH HHS UL1 TR002240NCATS NIH HHS UL1 TR002548NCRR NIH HHS UL1 RR024134NCRR NIH HHS UL1 RR025752NCRR NIH HHS UL1 RR025755NCRR NIH HHS UL1 RR025771NHLBI NIH HHS HHSN268200900040CNHLBI NIH HHS HHSN268200900046CNHLBI NIH HHS HHSN268200900047CNHLBI NIH HHS HHSN268200900048CNHLBI NIH HHS HHSN268200900049CNIA NIH HHS T32 AG000212NIDDK NIH HHS K23 DK114556NIDDK NIH HHS K24 DK110427NIDDK NIH HHS R01 DK098234NIGMS NIH HHS P30 GM103337
Abstract
Chronic kidney disease is a strong risk factor for cardiovascular disease (CVD), but clinical kidney measures (estimated glomerular filtration rate and albuminuria) do not fully reflect the multiple aspects of kidney tubules influencing cardiovascular health. Applied methods are needed to integrate numerous tubule biomarkers into useful prognostic scores. In SPRINT (Systolic Blood Pressure Intervention Trial) participants with chronic kidney disease at baseline (estimated glomerular filtration rate
Indexed as
AgedAged, 80 and overBiomarkersBlood PressureCardiovascular DiseasesCreatinineFemaleGlomerular Filtration RateHumansKidneyMaleMiddle AgedRenal Insufficiency, ChronicRiskSurvival RateBiomarkersCreatininealbuminuriabiomarkercardiovascular diseasesepidemiologykidney
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