ArticleMolecular neurobiology2020
Gut Microbiota Dysbiosis Enhances Migraine-Like Pain Via TNFα Upregulation.
Article in Molecular neurobiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers, 2 of them syntheses that pooled it.
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Who cites it
54 citing papers in PubMed, 2 syntheses or guidelines pooled it, 85 citations in OpenAlex.
- Gut microbiota, probiotics, and migraine: a clinical review and meta-analysis.Journal of oral & facial pain and headache · 2025Pooled it
- Pooled it
- IgG positive food elimination diet altered gut microbiota, decreased zonulin in migraine adults: a pilot dietary intervention trial.Frontiers in nutrition · 2026Trial
- Targeting the microbiome in pediatric migraine: gastrointestinal manifestations and the therapeutic role ofGut microbes · 2026Article
- Two-sample Mendelian randomization study of gut microbiota and inflammatory proteins: Predictive, preventive, and personalized treatment for migraine.Neural regeneration research · 2026Article
- Serum tumor necrosis factor-α levels in migraine: a registry for migraine (REFORM) study.Pain reports · 2026Article
- Identification of common genetic and molecular signatures in migraine and comorbid conditions.The journal of headache and pain · 2026Review
- Review
- Acupuncture Alleviates Neuroinflammation in Chronic Migraine by Modulating Lactobacillus and Its Metabolite Pathways.Pain research & management · 2026Article
- A review on gut microbiota and migraine severity: a complex relationship.Inflammopharmacology · 2026Review
- Probiotic modulation of central and peripheral sensitization in a migraine model via the gut-brain-trigeminal axis.Scientific reports · 2025Article
- The Microbiota-Gut-Brain Connection: A New Horizon in Neurological and Neuropsychiatric Disorders.CNS neuroscience & therapeutics · 2025Review
- Neurophysiological Basis of Short-Chain Fatty Acid Action in Pain Modulation: Therapeutic Implications.International journal of molecular sciences · 2025Review
- Atrophy of hypothalamic subregions increases migraine risk: cross-sectional study and mendelian randomization analysis.The journal of headache and pain · 2025Article
- Dissecting Causal Relationships Between Gut Microbiota, Immunocyte Phenotype, and Migraine: A Mendelian Randomization Study.Brain and behavior · 2025Article
- The lactylation-immune regulatory axis: a potential therapeutic target for migraine prevention and treatment.The journal of headache and pain · 2025Article
- The Lung Microbiome Modulates Pain-Like Behavior Via the Lung-Brain Axis in a Nitroglycerin-Induced Chronic Migraine Mouse Model.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- The gut-masticatory muscles-temporomandibular joint pain axis-a scoping review.Journal of oral & facial pain and headache · 2025Article
- The Gut Microbiome and Migraine: Updates in Understanding.Current neurology and neuroscience reports · 2025Review
- Association between dietary index for gut microbiota and self-reported severe headache or migraine in U.S. adults: a cross-sectional study from NHANES.Frontiers in nutrition · 2025Article
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 2 countries.
Funding
Abstract
Migraine is one of the most disabling neurological diseases worldwide; however, the mechanisms underlying migraine headache are still not fully understood and current therapies for such pain are inadequate. It has been suggested that inflammation and neuroimmune modulation in the gastrointestinal tract could play an important role in the pathogenesis of migraine headache, but how gut microbiomes contribute to migraine headache is unclear. In the present study, we investigated the effect of gut microbiota dysbiosis on migraine-like pain using broad-spectrum antibiotics and germ-free (GF) mice. We observed that antibiotics treatment-prolonged nitroglycerin (NTG)-induced acute migraine-like pain in wild-type (WT) mice and the pain prolongation was completely blocked by genetic deletion of tumor necrosis factor-alpha (TNFα) or intra-spinal trigeminal nucleus caudalis (Sp5C) injection of TNFα receptor antagonist. The antibiotics treatment extended NTG-induced TNFα upregulation in the Sp5C. Probiotics administration significantly inhibited the antibiotics-produced migraine-like pain prolongation. Furthermore, NTG-induced migraine-like pain in GF mice was markedly enhanced compared to that in WT mice and gut colonization with fecal microbiota from WT mice robustly reversed microbiota deprivation-caused pain enhancement. Together, our results suggest that gut microbiota dysbiosis contributes to chronicity of migraine-like pain by upregulating TNFα level in the trigeminal nociceptive system.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.