Evidence map›Paper›PMID 31377994›Full record

ArticleNeuroinformatics2019

Response to "Fallacies of Mice Experiments".

Zhenyu Gao, Alyse M Thomas, Michael N Economo, Amada M Abrego, Karel Svoboda, Chris I De Zeeuw, Nuo Li

Abstract readLetterComment
In one paragraph

Article in Neuroinformatics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Zhenyu GaoDepartment of Neuroscience, Erasmus MC, Rotterdam, the Netherlands.
Alyse M ThomasDepartment of Neuroscience, Baylor College of Medicine, Houston, TX, 77030, USA.
Michael N EconomoJanelia Research Campus, Ashburn, VA, 20147, USA.
Amada M AbregoDepartment of Neuroscience, Baylor College of Medicine, Houston, TX, 77030, USA.
Karel SvobodaJanelia Research Campus, Ashburn, VA, 20147, USA.
Chris I De ZeeuwDepartment of Neuroscience, Erasmus MC, Rotterdam, the Netherlands.
Nuo LiDepartment of Neuroscience, Baylor College of Medicine, Houston, TX, 77030, USA. nuol@bcm.edu.ORCID 0000-0002-6613-5018

Funding

Multi-regional neural circuit dynamics underlying short-term memoryR21NS104781 · NINDS · BAYLOR COLLEGE OF MEDICINE · PI DRUCKMANN, SHAUL, LI, NUO · 2017 to 2018
$448k
NINDS NIH HHS R21 NS104781
6 · The paper itself

Abstract

In a recent Editorial, De Schutter commented on our recent study on the roles of a cortico-cerebellar loop in motor planning in mice (De Schutter 2019, Neuroinformatics, 17, 181-183, Gao et al. 2018, Nature, 563, 113-116). Two issues were raised. First, De Schutter questions the involvement of the fastigial nucleus in motor planning, rather than the dentate nucleus, given previous anatomical studies in non-human primates. Second, De Schutter suggests that our study design did not delineate different components of the behavior and the fastigial nucleus might play roles in sensory discrimination rather than motor planning. These comments are based on anatomical studies in other species and homology-based arguments and ignore key anatomical data and neurophysiological experiments from our study. Here we outline our interpretation of existing data and point out gaps in knowledge where future studies are needed.

Indexed as

Cerebellar NucleiCerebellumAnimalsMicePrimates

Identifiers

PMID31377994
PMCPMC6842428

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.