Evidence map›Paper›PMID 31377948›Full record

ArticleInflammation2019

H.pylori Infection Alleviates Acute and Chronic Colitis with the Expansion of Regulatory B Cells in Mice.

Xia Li, Jiang Tan, Feng Zhang, Qian Xue, Ning Wang, Xu Cong, Jingtong Wang

Abstract read
PubMed Publisher
In one paragraph

Article in Inflammation, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Bibliometric analysis of the correlation between H. pylori and inflammatory bowel disease.JGH open : an open access journal of gastroenterology and hepatology · 2024
    Review
  6. Review
  7. Immune Biology and Persistence of Helicobacter pylori in Gastric Diseases.Current topics in microbiology and immunology · 2023
    Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Synthesis of Interleukin-10 in Patients with Ulcerative Colitis andGastroenterology research and practice · 2020
    Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Xia LiDepartment of Geratology, Peking University People's Hospital, Beijing, 100044, China.
Jiang TanDepartment of Geratology, Peking University People's Hospital, Beijing, 100044, China.
Feng ZhangDepartment of Gastroenterology, Peking University People's Hospital, No. 11, Xizhimen South Street, Xicheng District, Beijing, 100044, China.
Qian XueDepartment of Geratology, Peking University People's Hospital, Beijing, 100044, China.
Ning WangDepartment of Geratology, Peking University People's Hospital, Beijing, 100044, China.
Xu CongPeking University Hepatology Institute, Peking University People's Hospital, Beijing, 100044, China.
Jingtong WangDepartment of Geratology, Peking University People's Hospital, Beijing, 100044, China. wangjingtong11@163.com.
Peking University People's Hospital · CNPeking University · CN

Funding

Beijing Natural Science Foundation 7162194National Natural Science Foundation of China 81370515National Natural Science Foundation of China 81770549
6 · The paper itself

Abstract

Epidemiological studies showed that there was an inverse relationship between Helicobacter pylori (H. pylori) infection and the incidence of inflammatory bowel diseases (IBD). Our previous research indicated that the regulatory immune responses induced by H. pylori infection were not limited to gastric mucosa, and the balance of intestinal mucosal immunity was influenced. In this study, mice were infected with H. pylori SS1, and then colitis was induced by 3% dextran sulphate sodium (DSS), to investigate the role of the regulatory B cells in the effects of H. pylori infection on acute and chronic colitis. In acute and chronic colitis groups, DAI and colonic histological scores reduced significantly and colon length shorted less, the proinflammatory cytokines mRNA expression downregulated in colonic mucosa, and the percentages of CD19

Indexed as

Cell ProliferationHelicobacter pyloriAnimalsAntigens, CD19B-Lymphocytes, RegulatoryColitisCytokinesDextran SulfateHelicobacter InfectionsInterleukin-10MiceAntigens, CD19CD19 antigen, mouseCytokinesDextran SulfateInterleukin-10Helicobacter pyloriInflammatory bowel diseasesRegulatory B cellsRegulatory T cells

Identifiers

PMID31377948
OpenAlexW2965954415

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.