ArticleJournal of medical ultrasonics (2001)2019
Contrast-enhanced harmonic endoscopic ultrasound using time-intensity curve analysis predicts pathological grade of pancreatic neuroendocrine neoplasm.
Article in Journal of medical ultrasonics (2001), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- The role of quantitative contrast-enhanced endoscopic ultrasound in the differential diagnosis of pancreatic solid neoplasms: a proof-of-concept prospective study shifting from subjective to objective.iGIE : innovation, investigation and insights · 2026Article
- Review
- Applications and Prospects of Artificial Intelligence-Assisted Endoscopic Ultrasound in Digestive System Diseases.Diagnostics (Basel, Switzerland) · 2023Review
- Contrast Enhanced EUS for Predicting Solid Pancreatic Neuroendocrine Tumor Grade and Aggressiveness.Diagnostics (Basel, Switzerland) · 2023Review
- Prediction of Pathological Grades of Pancreatic Neuroendocrine Tumors Based on Dynamic Contrast-Enhanced Ultrasound Quantitative Analysis.Diagnostics (Basel, Switzerland) · 2023Article
- Contrast-Enhanced Harmonic Endoscopic Ultrasound for Diagnosis of the Aggressiveness of Pancreatic Neuroendocrine Neoplasm.Diagnostics (Basel, Switzerland) · 2022Article
- Early Assessment of Chemoradiotherapy Response for Locally Advanced Pancreatic Ductal Adenocarcinoma by Dynamic Contrast-Enhanced Ultrasound.Diagnostics (Basel, Switzerland) · 2022Article
- Diagnosis, treatment, and current concepts in the endoscopic management of gastroenteropancreatic neuroendocrine neoplasms.World journal of gastroenterology · 2022Review
- Advances in the imaging of gastroenteropancreatic neuroendocrine neoplasms.World journal of gastroenterology · 2022Review
- Current updates and future directions in diagnosis and management of gastroenteropancreatic neuroendocrine neoplasms.World journal of gastrointestinal endoscopy · 2022Review
- Transabdominal ultrasonographic diagnosis of relatively rare pancreatic neoplasms.Journal of medical ultrasonics (2001) · 2022Review
- Diagnostic and Interventional Role of Endoscopic Ultrasonography for the Management of Pancreatic Neuroendocrine Neoplasms.Journal of clinical medicine · 2021Review
- Role of Endoscopic Ultrasound in the Diagnosis of Pancreatic Neuroendocrine Neoplasms.Diagnostics (Basel, Switzerland) · 2021Review
- Calcitonin-negative neuroendocrine tumor of the thyroid with metastasis to liver-rare presentation of an unusual tumor: A case report and review of literature.World journal of clinical cases · 2020Article
- Contrast-enhanced harmonic EUS with time-intensity curve analysis useful for diagnosis of pancreatic metastasis from renal cell carcinoma (with videos).Endoscopic ultrasoundArticle
- Do we need contrast agents for EUS?Endoscopic ultrasoundReview
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeHistological grading is important for the treatment algorithm in pancreatic neuroendocrine neoplasms (PNEN). The present study examined the efficacy of contrast-enhanced harmonic endoscopic ultrasound (CH-EUS) and time-intensity curve (TIC) analysis of PNEN diagnosis and grading.
methodsTIC analysis was performed in 30 patients using data obtained from CH-EUS, and a histopathological diagnosis was made via EUS-guided fine-needle aspiration or surgical resection. The TIC parameters were analyzed by dividing them into G1/G2 and G3/NEC groups. Then, patients were classified into non-aggressive and aggressive groups and evaluated.
resultsTwenty-six patients were classified as G1/G2, and four as G3/NEC. From the TIC analysis, five parameters were obtained (I: echo intensity change, II: time for peak enhancement, III: speed of contrast, IV: decrease rate for enhancement, and V: enhancement ratio for node/pancreatic parenchyma). Three of these parameters (I, IV, and V) showed high diagnostic performance. Using the cutoff value obtained from the receiver-operating characteristic (ROC) analysis, the correct diagnostic rates of parameters I, IV, and V were 96.7%, 100%, and 100%, respectively, between G1/G2 and G3/NEC. A total of 21 patients were classified into the non-aggressive group, and nine into the aggressive group. Using the cutoff value obtained from the ROC analysis, the accurate diagnostic rates of I, IV, and V were 86.7%, 86.7%, and 88.5%, respectively, between the non-aggressive and aggressive groups.
conclusionCH-EUS and TIC analysis showed high diagnostic accuracy for grade diagnosis of PNEN. Quantitative perfusion analysis is useful to predict PNEN grade diagnosis preoperatively.
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