Evidence map›Paper›PMID 31377935›Full record

ArticleEuropean journal of epidemiology2019

Assisted reproductive technology and risk of ovarian cancer and borderline tumors in parous women: a population-based cohort study.

Frida E Lundberg, Anna L V Johansson, Kenny Rodriguez-Wallberg, Kristina Gemzell-Danielsson, Anastasia N Iliadou

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of epidemiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 2 pooled it
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 2 syntheses or guidelines pooled it, 48 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Review
  5. Article
  6. Article
  7. Review
  8. Observational
  9. Review
  10. Article
  11. Specialty Grand Challenge-Assisted Reproduction.Frontiers in reproductive health · 2021
    Article
  12. Article
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Frida E LundbergDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden. frida.lundberg@ki.se.ORCID http://orcid.org/0000-0001-7061-7178
Anna L V JohanssonDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.ORCID http://orcid.org/0000-0002-1191-7231
Kenny Rodriguez-WallbergDepartment of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden.ORCID http://orcid.org/0000-0003-4378-6181
Kristina Gemzell-DanielssonDivision of Obstetrics and Gynecology, Department of Women's and Children's Health, Karolinska Institutet and Karolinska University Hospital, WHO Collaborating Centre, Stockholm, Sweden.ORCID http://orcid.org/0000-0001-6516-1444
Anastasia N IliadouDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.ORCID http://orcid.org/0000-0002-5482-0675
Karolinska Institutet · SEKarolinska University Hospital · SE

Funding

FP7 Research infrastructures 259679Karolinska Institutet Strategic Research Program in Epidemiology Young Scholar AwardsVetenskapsrådet K2011-69X-21871-01-6Vetenskapsrådet SIMSAM 340-2013-5867
6 · The paper itself

Abstract

The study aimed to investigate if assisted reproductive technology (ART) treatment or a diagnosis of infertility were associated with the risk of ovarian cancer or borderline ovarian tumors (BOT) in parous women. In a population-based register study of 1,340,097 women with a first live birth in Sweden 1982-2012, the relationship between ART treatments, infertility and incidence of ovarian cancer or BOT were investigated using Cox regression analysis. In the cohort, 38,025 women gave birth following ART, 49,208 following an infertility diagnosis but no ART and 1,252,864 without infertility diagnosis or ART. During follow-up, 991 women were diagnosed with ovarian cancer and 747 with BOT. Women who gave birth following ART had higher incidence of both ovarian cancer (adjusted hazard ratio [aHR] 2.43, 95% confidence interval [CI] 1.73-3.42) and BOT (aHR 1.91, 95% CI 1.27-2.86), compared to women without infertility. Compared to women with infertility diagnoses and non-ART births, women with ART births also had a higher incidence of ovarian cancer (aHR 1.79, 95% CI 1.18-2.71) and BOT (aHR 1.48, 95% CI 0.90-2.44). Our results suggest that women who have gone through ART have a higher risk of ovarian cancer and BOT. At least part of that risk seems to be due to the underlying infertility and not the treatment per se, since the increased risk was smaller when comparing to other infertile women. As ART treatments are becoming more common and ovarian cancer usually occur in women of advanced age, larger studies with longer follow-up are needed in order to confirm or refute our findings.

Indexed as

AdultCohort StudiesFemaleFertilization in VitroHumansIncidenceInfertility, FemaleNeoplasmsOvarian NeoplasmsOvulation InductionPregnancyReproductive Techniques, AssistedRisk FactorsSwedenAssisted reproductive technologyBorderline ovarian tumorInfertilityIn vitro fertilizationOvarian cancerOvarian stimulation

Identifiers

PMID31377935
PMCPMC6861355
OpenAlexW2966425577

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.