Evidence map›Paper›PMID 31377870›Full record

ArticleMedical microbiology and immunology2019

Pseudomonas aeruginosa quorum-sensing molecule N-(3-oxo-dodecanoyl)-L-homoserine lactone triggers mitochondrial dysfunction and apoptosis in neutrophils through calcium signaling.

Pradeep Kumar Singh, Vivek Kumar Yadav, Manmohit Kalia, Deepmala Sharma, Deepak Pandey, Vishnu Agarwal

Abstract read
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In one paragraph

Article in Medical microbiology and immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 17 citations in OpenAlex.

  1. mSphere · 2026
    Article
  2. bioRxiv : the preprint server for biology · 2025
    Article
  3. Heliyon · 2023
    Article
  4. Article
  5. Review
  6. Review
  7. Review
  8. Frontiers in microbiology · 2020
    Article
  9. Impact ofFrontiers in immunology · 2020
    Review
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Pradeep Kumar SinghDepartment of Biotechnology, Motilal Nehru National Institute of Technology Allahabad, Prayagraj, Uttar Pradesh, 211004, India.
Vivek Kumar YadavDepartment of Biotechnology, Motilal Nehru National Institute of Technology Allahabad, Prayagraj, Uttar Pradesh, 211004, India.
Manmohit KaliaDepartment of Biotechnology, Motilal Nehru National Institute of Technology Allahabad, Prayagraj, Uttar Pradesh, 211004, India.
Deepmala SharmaDepartment of Mathematics, National Institute of Technology Raipur, Raipur, Chhattisgarh, 492010, India.
Deepak PandeyDepartment of Reproductive Biology, All India Institute of Medical Sciences, New Delhi, 110029, India.
Vishnu AgarwalDepartment of Biotechnology, Motilal Nehru National Institute of Technology Allahabad, Prayagraj, Uttar Pradesh, 211004, India. vishnua@mnnit.ac.in.ORCID http://orcid.org/0000-0002-7060-4454
Motilal Nehru National Institute of Technology · INAll India Institute of Medical Sciences · INNational Institute of Technology Raipur · IN

Funding

Department of Biotechnology , Ministry of Science and Technology BT/PR6175/GBD/27/367/2012Science and Engineering Research Board EMR/2014/000496
6 · The paper itself

Abstract

Pseudomonas aeruginosa is an opportunistic pathogen that utilizes the quorum-sensing (QS) process to regulate the production of different virulence factors and biofilm. N-3-oxo-dodecanoyl-L-homoserine lactone (C12) is a key QS molecule of P. aeruginosa which interacts with the mammalian immune cells and modulates their function. Here, we investigated the molecular mechanism of C12-induced apoptosis in neutrophils. Our data show that C12 causes apoptosis in neutrophils through an elevation in cytosolic and mitochondrial Ca

Indexed as

Apoptosis4-ButyrolactoneCalcium SignalingHealthy VolunteersHomoserineHumansMitochondriaNeutrophilsPseudomonas aeruginosa4-ButyrolactoneHomoserineN-(3-oxododecanoyl)homoserine lactoneApoptosisCalcium signalingmCUMitochondriaNeutrophilROS

Identifiers

PMID31377870
OpenAlexW2966267977

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.