Evidence map›Paper›PMID 31377781›Full record

ArticleRheumatology (Oxford, England)2020

Damage accrual and mortality over long-term follow-up in 300 patients with systemic lupus erythematosus in a multi-ethnic British cohort.

Beatriz Tejera Segura, Brett Sydney Bernstein, Thomas McDonnell, Chris Wincup, Vera M Ripoll, Ian Giles, David Isenberg, Anisur Rahman

Erratum issuedOpen access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Rheumatology (Oxford, England), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 34 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed, 4 pooled it
3.9field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 4 syntheses or guidelines pooled it, 46 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Beatriz Tejera SeguraCentre for Rheumatology Research, Division of Medicine, University College London, London, UK.
Brett Sydney BernsteinCentre for Rheumatology Research, Division of Medicine, University College London, London, UK.
Thomas McDonnellCentre for Rheumatology Research, Division of Medicine, University College London, London, UK.
Chris WincupCentre for Rheumatology Research, Division of Medicine, University College London, London, UK.
Vera M RipollCentre for Rheumatology Research, Division of Medicine, University College London, London, UK.
Ian GilesCentre for Rheumatology Research, Division of Medicine, University College London, London, UK.
David IsenbergCentre for Rheumatology Research, Division of Medicine, University College London, London, UK.
Anisur RahmanCentre for Rheumatology Research, Division of Medicine, University College London, London, UK.
University College London · GB

Funding

Medical Research Council MR/P017371/1Versus Arthritis 21992
6 · The paper itself

Abstract

objectiveDamage in patients with systemic lupus erythematosus is irreversible change in organs due to disease activity, concomitant disease or medication side-effects. It is measured using the Systemic Lupus International Collaborative Clinics Damage Index (SDI) and is associated with increased mortality. Previous reports have suggested associations between damage accrual and various ethnic, disease and treatment factors, but there is a dearth of long-term follow-up data from large multi-ethnic cohorts. We describe a study of damage and mortality in 300 patients from London, UK followed for up to 40 years.

methodsWe carried out retrospective analysis of medical records and SDI scores of 300 patients followed for up to 40 years (median 13.3 years). Characteristics of the groups who did and did not develop damage and those who died or survived to the end of follow-up were compared using univariable and multivariable analysis. Kaplan-Meier analysis was used to analyse factors affecting mortality and accrual of damage.

resultsDamage developed in 231/300 (77%) of patients. There was a linear accrual of damage over 40 years follow-up. Factors associated with damage were African/Caribbean ethnicity, renal and cerebral involvement, early use of high-dose corticosteroids or immunosuppressants, anti-RNP and antiphospholipid antibodies. Damage was strongly associated with mortality. Of 87 patients who died, 93% had damage compared with 70% of survivors (P < 0.001).

conclusionDevelopment of damage is strongly associated with increased mortality. We identified groups at increased risk of developing damage, including those treated with high-dose steroids and immunosuppressants within the first two years.

Indexed as

Adrenal Cortex HormonesAdultDisease ProgressionFemaleFollow-Up StudiesHumansImmunosuppressive AgentsLupus Erythematosus, SystemicMaleMiddle AgedRetrospective StudiesSeverity of Illness IndexSurvival RateUnited KingdomAdrenal Cortex HormonesImmunosuppressive AgentsdamagemortalitySystemic lupus erythematosus

Identifiers

PMID31377781
PMCPMC8414923
OpenAlexW2965066413

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.