Evidence map›Paper›PMID 31377713›Full record

ArticleBMJ open2019

Protocolized Post-Extubation Respiratory Support to prevent reintubation: protocol and statistical analysis plan for a clinical trial.

Jonathan Dale Casey, Erin R Vaughan, Bradley D Lloyd, Peter A Bilas, Eric J Hall, Alexandra H Toporek, Kevin G Buell, Ryan M Brown, Roger K Richardson, J Craig Rooks and 8 more

Registry-linked trialOpen access · goldAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ open, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03288311 (Protocolized Post-Extubation Respiratory Support), which is not on this map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03288311 nacompletednot on this map

Protocolized Post-Extubation Respiratory Support (PROPER) Study

TypeinterventionalSponsorVanderbilt University Medical CenterRan2017 to 2019Enrolled751ConditionsMechanical Ventilation Complication, Acute Respiratory Failure, Intubation ComplicationArmsProtocolized post-extubation respiratory support, Usual Care
3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Trial
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 2 institutions in 1 country.

Jonathan Dale CaseyDivision of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.ORCID 0000-0002-0977-290X
Erin R VaughanDivision of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Bradley D LloydDivision of Respiratory Care, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Peter A BilasDepartment of Anesthesiology, University of Florida, Gainesville, Florida, USA.
Eric J HallDepartment of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Alexandra H ToporekDepartment of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Kevin G BuellDepartment of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Ryan M BrownDivision of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Roger K RichardsonDivision of Respiratory Care, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
J Craig RooksDivision of Respiratory Care, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Li WangDepartment of Biostatistics, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Christopher J LindsellDepartment of Biostatistics, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
E Wesley ElyDivision of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Wesley H SelfDepartment of Emergency Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Gordon R BernardDivision of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Todd W RiceDivision of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Matthew W SemlerDivision of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Pragmatic Critical Care Research Group
Vanderbilt University Medical Center · USUniversity of Florida · US

Funding

Vanderbilt Institute for Clinical and Translational Research (VICTR) -Identifying correlates of functional immunity in SARS-CoV-2 convalescent plasmaUL1TR002243 · NCATS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Paul A. Harris, Wesley H Self · 2017 to 2026
$130.7M
The Vanderbilt Institute for Clinical and Translational Research (VICTR)UL1TR000445 · NCATS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BERNARD, GORDON RAPHAEL · 2012 to 2016
$41.4M
Clinical and Translational Training Program in Pulmonary MedicineT32HL087738 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Lorraine B Ware · 2007 to 2026
$7.0M
The Vanderbilt Emergency Care Research Training ProgramK12HL133117 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI STORROW, ALAN B · 2016 to 2020
$1.9M
Oxygen Saturation Targets during Mechanical Ventilation of Critically Ill Adults: A Clinical TrialK23HL143053 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI SEMLER, MATTHEW WALL · 2018 to 2022
$854k
Citrulline to Prevent or Mitigate Acute Lung Injury in Severe SepsisR34HL105869 · NHLBI · VANDERBILT UNIVERSITY · PI RICE, TODD W · 2012 to 2014
$686k
NCATS NIH HHS UL1 TR000445NCATS NIH HHS UL1 TR002243NHLBI NIH HHS K12 HL133117NHLBI NIH HHS K23 HL143053NHLBI NIH HHS R34 HL105869NHLBI NIH HHS T32 HL087738
6 · The paper itself

Abstract

introductionFollowing extubation from invasive mechanical ventilation, nearly one in seven critically ill adults requires reintubation. Reintubation is independently associated with increased mortality. Postextubation respiratory support (non-invasive ventilation or high-flow nasal cannula applied at the time of extubation) has been reported in small-to-moderate-sized trials to reduce reintubation rates among hypercapnic patients, high-risk patients without hypercapnia and low-risk patients without hypercapnia. It is unknown whether protocolised provision of postextubation respiratory support to every patient undergoing extubation would reduce the overall reintubation rate, compared with usual care. METHODS AND ANALYSIS: The Protocolized Post-Extubation Respiratory Support (PROPER) trial is a pragmatic, cluster cross-over trial being conducted between 1 October 2017 and 31 March 2019 in the medical intensive care unit of Vanderbilt University Medical Center. PROPER compares usual care versus protocolized post-extubation respiratory support (a respiratory therapist-driven protocol that advises the provision of non-invasive ventilation or high-flow nasal cannula based on patient characteristics). For the duration of the trial, the unit is divided into two clusters. One cluster receives protocolised support and the other receives usual care. Each cluster crosses over between treatment group assignments every 3 months. All adults undergoing extubation from invasive mechanical ventilation are enrolled except those who received less than 12 hours of mechanical ventilation, have 'Do Not Intubate' orders, or have been previously reintubated during the hospitalisation. The anticipated enrolment is approximately 630 patients. The primary outcome is reintubation within 96 hours of extubation. ETHICS AND DISSEMINATION: The trial was approved by the Vanderbilt Institutional Review Board. The results will be submitted for publication in a peer-reviewed journal and presented at one or more scientific conferences. TRIAL REGISTRATION NUMBER: NCT03288311.

Indexed as

Airway ExtubationIntubation, IntratrachealCross-Over StudiesData Interpretation, StatisticalHumansPragmatic Clinical Trials as TopicRespiration, ArtificialRetreatmentrespiratory physiology

Identifiers

PMID31377713
PMCPMC6687016
OpenAlexW2965530592

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.