Evidence map›Paper›PMID 31377667›Full record

ArticleiScience2019

Charge Regulation of Self-Assembled Tubules by Protonation for Efficiently Selective and Controlled Drug Delivery.

Liping Huang, Hang Zhang, Shanshan Wu, Xin Xu, Lingling Zhang, Hongbing Ji, Liang He, Yuna Qian, Zhiyong Wang, Yongming Chen and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.7field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

Liping HuangFine Chemical Industry Research Insitute, Key Laboratory for Polymeric Composite & Functional Materials of Ministry of Education and MOE Key Laboratory of Bioinorganic and Synthetic Chemistry Lab, School of Chemistry, Sun Yat-sen University, Guangzhou 510275, PR China.
Hang ZhangFine Chemical Industry Research Insitute, Key Laboratory for Polymeric Composite & Functional Materials of Ministry of Education and MOE Key Laboratory of Bioinorganic and Synthetic Chemistry Lab, School of Chemistry, Sun Yat-sen University, Guangzhou 510275, PR China.
Shanshan WuFine Chemical Industry Research Insitute, Key Laboratory for Polymeric Composite & Functional Materials of Ministry of Education and MOE Key Laboratory of Bioinorganic and Synthetic Chemistry Lab, School of Chemistry, Sun Yat-sen University, Guangzhou 510275, PR China.
Xin XuFine Chemical Industry Research Insitute, Key Laboratory for Polymeric Composite & Functional Materials of Ministry of Education and MOE Key Laboratory of Bioinorganic and Synthetic Chemistry Lab, School of Chemistry, Sun Yat-sen University, Guangzhou 510275, PR China.
Lingling ZhangFine Chemical Industry Research Insitute, Key Laboratory for Polymeric Composite & Functional Materials of Ministry of Education and MOE Key Laboratory of Bioinorganic and Synthetic Chemistry Lab, School of Chemistry, Sun Yat-sen University, Guangzhou 510275, PR China.
Hongbing JiFine Chemical Industry Research Insitute, Key Laboratory for Polymeric Composite & Functional Materials of Ministry of Education and MOE Key Laboratory of Bioinorganic and Synthetic Chemistry Lab, School of Chemistry, Sun Yat-sen University, Guangzhou 510275, PR China.
Liang HeFine Chemical Industry Research Insitute, Key Laboratory for Polymeric Composite & Functional Materials of Ministry of Education and MOE Key Laboratory of Bioinorganic and Synthetic Chemistry Lab, School of Chemistry, Sun Yat-sen University, Guangzhou 510275, PR China.
Yuna QianState Key Laboratory of Ophthalmology, Optometry and Vision Science, School of Ophthalmology and Optometry, School of Biomedical Engineering, Wenzhou Medical University, Wenzhou 325027, PR China; Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou 325001, PR China.
Zhiyong WangKey Laboratory for Polymeric Composite & Functional Materials of Ministry of Education, School of Materials Science and Engineering, Sun Yat-sen University, Guangzhou 510275, PR China.
Yongming ChenKey Laboratory for Polymeric Composite & Functional Materials of Ministry of Education, School of Materials Science and Engineering, Sun Yat-sen University, Guangzhou 510275, PR China.
Jianliang ShenState Key Laboratory of Ophthalmology, Optometry and Vision Science, School of Ophthalmology and Optometry, School of Biomedical Engineering, Wenzhou Medical University, Wenzhou 325027, PR China; Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou 325001, PR China. Electronic address: shenjl@wibe.ac.cn.
Zong-Wan MaoFine Chemical Industry Research Insitute, Key Laboratory for Polymeric Composite & Functional Materials of Ministry of Education and MOE Key Laboratory of Bioinorganic and Synthetic Chemistry Lab, School of Chemistry, Sun Yat-sen University, Guangzhou 510275, PR China. Electronic address: cesmzw@mail.sysu.edu.cn.
Zhegang HuangFine Chemical Industry Research Insitute, Key Laboratory for Polymeric Composite & Functional Materials of Ministry of Education and MOE Key Laboratory of Bioinorganic and Synthetic Chemistry Lab, School of Chemistry, Sun Yat-sen University, Guangzhou 510275, PR China. Electronic address: huangzhg3@mail.sysu.edu.cn.
Sun Yat-sen University · CNWenzhou Medical University · CNWenzhou University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Despite the success for targeted delivery in the body, the efficient release without side effects caused by residual drug remains a challenge. For reducing residual drug, the pH-responsive carriers were prepared by self-assembly from aromatic macrocycles, which were non-toxic and biocompatible. The inner surroundings of aromatic macrocycles could be protonated positively by acid inducing the separation of neighboring macrocycles. Thus, Dox-loaded carriers successfully inhibited the proliferation of carcinoma cells (HepG2 and 4T1) rather than normal cells (HL7702). The effects were further proved in vivo without systemic cytotoxicity. Notably, the responsive environment for drug release depended on the concentration of carriers. Particularly, drug release was promoted by carrier separation. Carrier 2 exhibited preferable anticancer efficacy than carrier 1 due to the efficient release of Dox by full separation of the carrier. Collectively, we have developed a novel strategy serving as a selective and controlled drug release platform for cancer therapeutics.

Indexed as

BiomaterialsDrug Delivery SystemSupramolecular Materials

Identifiers

PMID31377667
PMCPMC6698284
OpenAlexW2962941044

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.