ArticleFree radical biology & medicine2019
Cholestatic liver disease results increased production of reactive aldehydes and an atypical periportal hepatic antioxidant response.
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Article in Free radical biology & medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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12citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
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Who cites it
12 citing papers in PubMed, 21 citations in OpenAlex.
- Rapid protein carbonylation and decreased insulin secretion induced by inflammatory oxidative stress compounds.Free radical biology & medicine · 2026Article
- Cholestatic and autoimmune liver diseases, bile duct injury, oxidative stress, and therapeutic strategies.Frontiers in physiology · 2026Review
- A magnetic resonance image-based deep learning radiomics nomogram for hepatocyte cytokeratin 7 expression: application to predict cholestasis progression in children with pancreaticobiliary maljunction.Pediatric radiology · 2025Article
- Scars of oxidative stress: protein carbonylation and beta cell dysfunction in diabetes.Frontiers in endocrinology · 2025Review
- Activation of Nrf2/HO-1 signaling pathway exacerbates cholestatic liver injury.Communications biology · 2024Article
- Article
- Licraside as novel potent FXR agonist for relieving cholestasis: structure-based drug discovery and biological evaluation studies.Frontiers in pharmacology · 2023Article
- The Nrf2 Pathway in Liver Diseases.Frontiers in cell and developmental biology · 2022Review
- The autophagic protein p62 is a target of reactive aldehydes in human and murine cholestatic liver disease.PloS one · 2022Article
- Heme Oxygenase-1 Induction by Cobalt Protoporphyrin Ameliorates Cholestatic Liver Disease in a Xenobiotic-Induced Murine Model.International journal of molecular sciences · 2021Article
- Supplemental Ascorbate Diminishes DNA Damage Yet Depletes Glutathione and Increases Acute Liver Failure in a Mouse Model of Hepatic Antioxidant System Disruption.Antioxidants (Basel, Switzerland) · 2021Article
- Effect of neuronal nitric oxide synthase serine-1412 phosphorylation on hypothalamic-pituitary-ovarian function and leptin response.Biology of reproduction · 2020Article
Corrections and comments
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Authors and funding
14 authors at 3 institutions in 1 country.
Colin T ShearnDepartment of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Aurora, CO, 80045, United States. Electronic address: Colin.Shearn@ucdenver.edu.
Blair FennimoreDepartment of Medicine, School of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, 80045, United States.
David J OrlickyDepartment of Pathology, School of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, 80045, United States.
Yue R GaoDepartment of Medicine, School of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, 80045, United States.
Laura M SabaDepartment of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Aurora, CO, 80045, United States.
Kayla D BattistaDepartment of Medicine, School of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, 80045, United States.
Stefanos AivazidisDepartment of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Aurora, CO, 80045, United States.
Mohammed AssiriDepartment of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Aurora, CO, 80045, United States.
Peter S HarrisDepartment of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Aurora, CO, 80045, United States.
Cole MichelDepartment of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Aurora, CO, 80045, United States.
Gary F MerrillDepartment of Biochemistry and Biophysics, Oregon State University, Corvalis, OR, 97331, United States.
Edward E SchmidtDepartment of Microbiology and Immunology, Montana State University, Bozeman, MT, 59717, United States.
Sean P ColganDepartment of Medicine, School of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, 80045, United States.
Dennis R PetersenDepartment of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Aurora, CO, 80045, United States.
University of Colorado Anschutz Medical Campus · USMontana State University · USOregon State University · US
Funding
University of Colorado Cancer Center Support Grant - Lung Cancer Patient-Derived Xenografts with Autologous Human Immune SystemsP30CA046934 · NCI · UNIVERSITY OF COLORADO DENVER · PI James V Degregori · 1988 to 2026
$117.0MCTSA INFRASTRUCTURE FOR PEDIATRIC RESEARCHUL1RR025780 · NCRR · UNIVERSITY OF COLORADO DENVER · PI SOKOL, RONALD J. · 2008 to 2011
$61.3MPILOT STUDY--SUBSTRATE METABOLISM IN EXTREMELY LOW BIRTH WEIGHT INFANTSP30DK048520 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI JANINE A HIGGINS · 1995 to 2026
$32.6MMechanisms of Adenosine ProtectionR01DK095491 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI Sean P Colgan · 2012 to 2026
$4.9MMetabolic Regulation of Inflammation by Microbial SCFAR01DK104713 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI Sean P Colgan · 2015 to 2026
$4.7MLipid Aldehyde and Ethanol Induced Liver DamageR37AA009300 · NIAAA · UNIVERSITY OF COLORADO DENVER · PI PETERSEN, DENNIS · 2008 to 2017
$4.4MHypoxia, HIF, and Mucosal InflammationR37DK050189 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI COLGAN, SEAN P · 2010 to 2019
$4.1MGASTROINTESTINAL DISEASE TRAINING GRANTT32DK007038 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI COLGAN, SEAN P · 1986 to 2020
$3.5MLIPID ALDEHYDES AND ETHANOL-INDUCED LIVER INJURYR01AA009300 · NIAAA · UNIVERSITY OF COLORADO DENVER · PI PETERSEN, DENNIS · 1993 to 2005
$2.1MMETABOLIC CONTROL OF EPITHELIAL AUTOPHAGY DURING INFLAMMATIONR01DK103712 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI COLGAN, SEAN P · 2015 to 2019
$1.7MMetabolic basis of the NADPH-independent disulfide reductase system in mouse liverR01DK123738 · NIDDK · MONTANA STATE UNIVERSITY - BOZEMAN · PI DENICOLA, GINA MARIE, SCHMIDT, EDWARD E · 2020 to 2022
$1.3MMetabolic basis of the NADPH-independent disulfide reductase system in mouse liverR56DK123738 · NIDDK · MONTANA STATE UNIVERSITY - BOZEMAN · PI DENICOLA, GINA MARIE, SCHMIDT, EDWARD E · 2019 to 2019
$464kBLRD VA I01 BX002182NCI NIH HHS P30 CA046934NCRR NIH HHS UL1 RR025780NIAAA NIH HHS R01 AA009300NIAAA NIH HHS R37 AA009300NIDDK NIH HHS P30 DK048520NIDDK NIH HHS R01 DK095491NIDDK NIH HHS R01 DK103712NIDDK NIH HHS R01 DK104713NIDDK NIH HHS R01 DK123738NIDDK NIH HHS R37 DK050189NIDDK NIH HHS R56 DK123738NIDDK NIH HHS T32 DK007038NIH HHS R21 OD026444
Abstract
Cholangiopathies such as primary sclerosing cholangitis (PSC) are chronic liver diseases characterized by increased cholestasis, biliary inflammation and oxidative stress. The objective of this study was to elucidate the impact of cholestatic injury on oxidative stress-related factors. Using hepatic tissue and whole cell liver extracts (LE) isolated from 11-week old C57BL/6J (WT) and Mdr2
Indexed as
Oxidative StressAdultAldehydesAnimalsAntioxidantsCholestasisFemaleGlutathione TransferaseHumansInflammationLiverLiver DiseasesLysosomesMiceMice, Inbred C57BLMice, KnockoutAldehydesAntioxidantsGlutathione TransferaseNF-kappa BSuperoxide DismutaseSuperoxide Dismutase 2CholestasisInflammationLiverOxidative stressProtein carbonylationReactive aldehyde
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.