Evidence map›Paper›PMID 31377223›Full record

ReviewProgress in cardiovascular diseases

Diabetes, heart failure, and renal dysfunction: The vicious circles.

Eugene Braunwald

Abstract readReview
PubMed Publisher
In one paragraph

Review in Progress in cardiovascular diseases. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 108 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
108citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

108 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Trial
  4. Review
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. A Real-World Cohort Study of the Risks of Kidney Failure and Death in Diabetes.Clinical journal of the American Society of Nephrology : CJASN · 2026
    Article
  11. Article
  12. Article
  13. Article
  14. Observational
  15. Article
  16. Article
  17. Mechano-energetic uncoupling in heart failure.Nature reviews. Cardiology · 2025
    Review
  18. Article
  19. Article
  20. Review

48 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

1 author.

Eugene BraunwaldTIMI Study Group, Cardiovascular Division, Brigham and Women's Hospital, Department of Medicine, Harvard Medical School, Boston, MA, USA. Electronic address: ebraunwald@partners.org.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The prevalence of Type 2 diabetes mellitus (T2DM) has reached pandemic proportions. T2DM frequently causes macrovascular and/or microvascular pathologic changes and thereby increases the risks for the development of myocardial infarction, heart failure, stroke, renal failure, and reduced survival. This article describes the important interactions between T2DM, heart failure, and renal dysfunction, forming vicious circles. The interruption of these circles represents important therapeutic goals.

Indexed as

ComorbidityDiabetes Mellitus, Type 2Diabetic CardiomyopathiesDiabetic NephropathiesFemaleHeart FailureHumansMalePrevalencePrognosisRenal Insufficiency, ChronicSeverity of Illness IndexSurvival AnalysisUnited StatesCardiovascular diseaseChronic kidney diseaseDiabetes mellitusDiabetic kidney diseaseHeart failureType 2 diabetes mellitus

Identifiers

PMID31377223

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.