Evidence map›Paper›PMID 31377198›Full record

ArticleNeuropharmacology2019

Neuropeptide Y release in the rat spinal cord measured with Y1 receptor internalization is increased after nerve injury.

Juan Carlos Marvizon, Wenling Chen, Weisi Fu, Bradley K Taylor

Abstract read
In one paragraph

Article in Neuropharmacology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Juan Carlos MarvizonVatche and Tamar Manoukian Division of Digestive Diseases, 900 Veterans Ave., Warren Hall Building, Department of Medicine, David Geffen School of Medicine at the University of California Los Angeles, Los Angeles, CA, 90095, USA; Veteran Affairs Greater Los Angeles Healthcare System, 11310 Wilshire Blvd., Building 115, Los Angeles, CA, 90073, USA. Electronic address: enkephalin@protonmail.com.
Wenling ChenVatche and Tamar Manoukian Division of Digestive Diseases, 900 Veterans Ave., Warren Hall Building, Department of Medicine, David Geffen School of Medicine at the University of California Los Angeles, Los Angeles, CA, 90095, USA; Veteran Affairs Greater Los Angeles Healthcare System, 11310 Wilshire Blvd., Building 115, Los Angeles, CA, 90073, USA. Electronic address: WenLingChen@mednet.ucla.edu.
Weisi FuDepartment of Physiology, University of Kentucky Medical Center, Lexington, KY, USA. Electronic address: pencil2bfd@gmail.com.
Bradley K TaylorDepartment of Physiology, University of Kentucky Medical Center, Lexington, KY, USA; Department of Anesthesiology and Perioperative Medicine, Pittsburgh Center for Pain Research and the Pittsburgh Project to end Opioid Misuse, University of Pittsburgh, Pittsburgh, PA, USA. Electronic address: BKT@pitt.edu.

Funding

Pilot and Feasibility ProgramP30DK041301 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ROZENGURT, JUAN ENRIQUE · 1990 to 2019
$18.0M
NEUROPEPTIDERGIC INHIBITION OF SPINAL PAIN TRANSMISSIONR01NS045954 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BRADLEY K. TAYLOR · 2002 to 2026
$7.4M
PPAR Inhibition of Spinal Pain TransmissionR01NS062306 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI TAYLOR, BRADLEY K. · 2009 to 2021
$4.0M
Long-term activation of spinal opioid analgesia after inflammationR01DA037621 · NIDA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI TAYLOR, BRADLEY K. · 2015 to 2019
$3.4M
NMDA Receptors in Primary AfferentsR01DA033059 · NIDA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MARVIZON, JUAN CARLOS GARCIA, MCROBERTS, JAMES A · 2012 to 2016
$1.4M
Latent Sensitization and Neuropathic PainI01RX001646 · VA · VA GREATER LOS ANGELES HEALTHCARE SYSTEM · PI MARVIZON, JUAN CARLOS GARCIA · 2016 to 2018
–
NIDA NIH HHS R01 DA033059NIDA NIH HHS R01 DA037621NIDDK NIH HHS P30 DK041301NINDS NIH HHS R01 NS045954NINDS NIH HHS R01 NS062306RRD VA I01 RX001646
6 · The paper itself

Abstract

Neuropeptide Y (NPY) modulates nociception in the spinal cord, but little is known about its mechanisms of release. We measured NPY release in situ using the internalization of its Y1 receptor in dorsal horn neurons. Y1 receptor immunoreactivity was normally localized to the cell surface, but addition of NPY to spinal cord slices increased the number of neurons with Y1 internalization in a biphasic fashion (EC

Indexed as

6-Cyano-7-nitroquinoxaline-2,3-dioneAnimalsArginineCalcium Channel BlockersCapsaicinCyclic AMP-Dependent Protein KinasesExcitatory Amino Acid AntagonistsHyperalgesiaIndolesInterneuronsLidocaineMaleMicroscopy, ConfocalNeuropeptide YNociceptionomega-Conotoxins4-hydroxy-3,3-dimethyl-2H-benzo(g)indole-2,5(3H)-dione6-Cyano-7-nitroquinoxaline-2,3-dioneArginineBIBO 3304Calcium Channel BlockersCapsaicinCyclic AMP-Dependent Protein KinasesExcitatory Amino Acid AntagonistsIndolesLidocaineNeuropeptide Yneuropeptide Y-Y1 receptoromega-conotoxin-MVIIComega-ConotoxinsPotassium ChlorideProtein Tyrosine PhosphatasesReceptors, Neuropeptide YReceptors, N-Methyl-D-AspartateSensory System AgentsTrpv1 protein, ratTRPV Cation ChannelsVoltage-Gated Sodium Channel Blockers1548943)16132352)180081)22880)3132)439518)44093)5311022)56841670)6314)6604934)71077)94701)Amastatin (PubChem CIDBIBO3304 (PubChem CIDBVT948 (PubChem CIDcapsaicin (PubChem CIDcaptopril (PubChem CIDC-fiberdiprotin A (Ile-Pro-Iled-serine (PubChem CIDlidocaine (PubChem CIDMK-801 (PubChem CIDNeuropathic painneuropeptide Y (PubChem CIDNeurotransmitter releaseNMDA (PubChem CIDNociceptionPubChem CIDthiorphan (PubChem CIDω-conotoxin MVIIC (PubChem CID

Identifiers

PMID31377198
PMCPMC6904115

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.