ArticleNutrition, metabolism, and cardiovascular diseases : NMCD2019
Uric acid within the "normal" range predict 9-year cardiovascular mortality in older individuals. The InCHIANTI study.
Article in Nutrition, metabolism, and cardiovascular diseases : NMCD, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 19 citations in OpenAlex.
- The Nonlinear Relationship Between Serum Uric Acid and Cardiovascular Disease Risk: Mechanistic Insights and Clinical Implications.Cardiovascular drugs and therapy · 2026Review
- Higher serum uric acid levels and risk of all-cause mortality in general population: a systematic review and meta-analysis.Metabolism open · 2025Article
- The association of uric acid with mortality modifies at old age: data from the uric acid right for heart health (URRAH) study.Journal of hypertension · 2022Observational
- Association between Food Intake, Clinical and Metabolic Markers and DNA Damage in Older Subjects.Antioxidants (Basel, Switzerland) · 2021Article
- Long-term impact of baseline serum uric acid levels on living kidney donors: a retrospective study.BMC nephrology · 2021Article
- Uric Acid Variability and All-Cause Mortality: A Prospective Cohort Study in Northern China.The journal of nutrition, health & aging · 2021Article
- Pro-Aging Effects of Xanthine Oxidoreductase Products.Antioxidants (Basel, Switzerland) · 2020Review
- A Study of Cardiogenic Stroke Risk in Non-valvular Atrial Fibrillation Patients.Frontiers in cardiovascular medicine · 2020Article
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Authors and funding
11 authors at 5 institutions in 2 countries.
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Abstract
BACKGROUND AND
aimsIncreased uric acid levels correlate with cardiovascular disease and cardiovascular/overall mortality. To identify a uric acid threshold above which cardiovascular mortality rises, we studied the relationship between uric acid concentration and overall/cardiovascular mortality. METHODS AND
resultsWe analyzed data from the InCHIANTI study, a cohort study of Italian community-dwelling people with 9 years of follow-up. We selected a sample of 947 individuals over 64 years of age, free from cardio-cerebrovascular disease and with available uric acid measurement at baseline. The sample was divided according to plasma uric acid tertiles. The Hazard ratio (HR) for mortality was calculated by multivariate Cox proportional hazard model. Mean age of participants was 75.3 ± 7.3 years; the mean value of uric acid was 5.1 ± 1.4 mg/dl. Over 9-years of follow-up, 342 (36.1%) participants died, 143 deaths (15.1%) were due to cardiovascular disease. Subjects with higher uric acid concentrations presented a higher cardiovascular mortality [II (4.6-5.5 mg/dl) vs I (1.8-4.5 mg/dl) tertile HR: 1.98, 95%C.I. 1.22-3.23; III (≥5.6 mg/dl) vs I tertile HR: 1.87, 95%C.I. 1.13-3.09]. We found a non-linear association between uric acid concentrations and cardiovascular mortality with the lowest mortality for values of about 4.1 mg/dl and a significant risk increment for values above 4.3 mg/dl.
conclusionIn community-dwelling older individuals free from cardio-cerebrovascular events, the lowest 9-year cardiovascular mortality was observed for uric acid values far below current target values. If confirmed, these data might represent the background for investigating the efficacy of uric acid levels reduction in similar populations.
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