ArticleJournal of neuroscience methods2019
A rotating operant chamber for use with microdialysis.
Article in Journal of neuroscience methods, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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4 authors at 1 institution in 1 country.
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Abstract
backgroundRecently, the time resolution of microdialysis followed by a chemical separation for quantitative analysis has improved. The advent of faster microdialysis measurements promises to aid in behavioral research on awake animals. However, microdialysis with awake animals generally employs a fluidic commutator (swivel). The swivel's volume is inimical to the time resolution of the measurements. NEW
methodAnimals can be housed in rotating cages so that the swivel is not required, but rotating operant chambers are not available. Here we describe the design and construction of a rotating operant chamber with microdialysis capability. We modified a rotating cage by adding operant behavior testing components to the side of the bowl-shaped cage. A modular on-board controller facilitates operant component/computer communication. A battery provides power to the controller and the operant components. The battery and controller rotate with the cage, and the controller communicates with the computer wirelessly.
resultsThe rotating operant chamber can be used to train a rat to retrieve a sucrose pellet following a cue. Microdialysis and online liquid chromatography can be used to measure dopamine at one minute intervals while the rat moves freely and interacts with operant behavior testing components. COMPARISON WITH EXISTING METHOD(S): We are not aware of one-minute dopamine measurements in awake animals in an operant chamber.
conclusionsRotating cage modifications are straightforward. One-minute observations of striatal dopamine can be accomplished while an animal is awake, moving, and interacting with its surroundings.
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