ArticleInternational journal of radiation oncology, biology, physics2019
Lumpectomy Plus Hormone or Radiation Therapy Alone for Women Aged 70 Years or Older With Hormone Receptor-Positive Early Stage Breast Cancer in the Modern Era: An Analysis of the National Cancer Database.
Article in International journal of radiation oncology, biology, physics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 3 of them syntheses that pooled it.
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23 citing papers in PubMed, 3 syntheses or guidelines pooled it, 53 citations in OpenAlex.
- Efficacy of endocrine therapy alone versus endocrine therapy combined with radiotherapy after breast-conserving surgery in older patients with early-stage estrogen receptor-positive breast cancer: a meta-analysis.World journal of surgical oncology · 2026Pooled it
- Frequency of use and characterization of frailty assessments in observational studies on older women with breast cancer: a systematic review.BMC geriatrics · 2024Pooled it
- Socioeconomic Status and Breast Cancer Treatment in the United States: Results From a Systematic Literature Review.Cancer control : journal of the Moffitt Cancer CenterPooled it
- Drivers of Variation in the Rate of Radiotherapy Following Lumpectomy in the Military Health System.Breast cancer (Dove Medical Press) · 2026Article
- Adjuvant Radiation and Endocrine Therapy in Early-Stage Breast Cancer With Low Genomic Risk.JAMA network open · 2025Article
- "When Less is More": Paradigm Shifts in Radiation Treatment for Early-Stage Breast Cancer.Current treatment options in oncology · 2024Review
- Omission of adjuvant radiotherapy in low-risk elderly males with breast cancer.Breast cancer (Tokyo, Japan) · 2024Article
- Article
- Impact of non-adherence to endocrine therapy on recurrence risk in older women with stage I breast cancer after breast-conserving surgery.Breast cancer research and treatment · 2023Article
- Optimizing Adjuvant Treatment Recommendations for Older Women with Biologically Favorable Breast Cancer: Short-Course Radiation or Long-Course Endocrine Therapy?Current oncology (Toronto, Ont.) · 2022Review
- Accelerated Partial Breast Irradiation with Intraoperative Radiotherapy Is Effective in Luminal Breast Cancer Patients Aged 60 Years and Older.Journal of personalized medicine · 2022Article
- Personalising therapy for early-stage oestrogen receptor-positive breast cancer in older women.The lancet. Healthy longevity · 2022Review
- Experiences and Perceptions of Older Adults with Lower-Risk Hormone Receptor-Positive Breast Cancer about Adjuvant Radiotherapy and Endocrine Therapy: A Patient Survey.Current oncology (Toronto, Ont.) · 2021Article
- Ultra-Short Fraction Schedules as Part of De-intensification Strategies for Early-Stage Breast Cancer.Annals of surgical oncology · 2021Review
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- Article
- Breast cancer in women aged 75 years and older - tumour characteristics and treatment options.Przeglad menopauzalny = Menopause review · 2021Article
- Trends in Breast Cancer Treatment De-Implementation in Older Patients with Hormone Receptor-Positive Breast Cancer: A Mixed Methods Study.Annals of surgical oncology · 2021Article
- The Role of Radiation Therapy in the Older Patient.Current oncology reports · 2021Review
- Does persistent use of radiation in women > 70 years of age with early-stage breast cancer reflect tailored patient-centered care?Breast cancer research and treatment · 2020Article
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7 authors at 1 institution in 1 country.
Funding
Abstract
purposeDeintensification of adjuvant therapy is being considered for older women with early-stage, biologically favorable breast cancer. Although radiation therapy (RT) can be omitted in some cases, toxicity from hormone therapy (HT) is not trivial, and adherence rates vary. We hypothesized that adjuvant RT alone would produce survival outcomes comparable to those with adjuvant HT alone among elderly patients treated with lumpectomy. METHODS AND MATERIALS: We searched the National Cancer Database (2010-2014) for healthy women (aged ≥70 years, Charlson/Deyo [CD] score 0-1) with T1N0 hormone-receptor-positive, HER-2-negative breast cancer treated with lumpectomy and adjuvant HT or RT. Propensity scores were used to match patients for analysis.
resultsWe identified 2995 patients (median age, 78 years), most (81%) with a CD score of 0, clinical stage IA (77%), of whom 65% received HT alone and 35% received RT only after lumpectomy. On multivariate analysis of the matched cohort, older age (hazard ratio [HR] 1.10; 95% confidence interval [CI] 1.07-1.13; P < .001), CD score 1 (HR 1.92; 95% CI 1.37-2.70; P = .0002), and living in a metropolitan (vs urban) area (HR 3.09; 95% CI 1.43-6.67; P = .004) were associated with inferior overall survival (OS), whereas treatment with HT (vs RT) was not (HR 1.13; 95% CI 0.85-1.49; P = .406). At a median follow-up of 45 months, no difference was found in OS between HT versus RT cohorts (85% and 86%, respectively; P = .44).
conclusionsFor healthy, older women with biologically favorable breast cancer treated with lumpectomy, adjuvant RT or HT is associated with equivalent 5-year OS rates. A randomized controlled trial is warranted to explore these adjuvant monotherapy options in elderly patients with hormone receptor-positive breast cancer.
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