ArticleBrazilian journal of physical therapy
Alterations in knee sensorimotor brain functional connectivity contributes to ACL injury in male high-school football players: a prospective neuroimaging analysis.
Article in Brazilian journal of physical therapy. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04736511 (Study of the Influence of Proprioceptive Reweighting Ability on the Lower-extremity Biomechanics During Functional Tasks and Unplanned Sidestep Cutting Manoeuvre), which is not on this map. Cited by 26 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Study of the Influence of Proprioceptive Reweighting Ability on the Lower-extremity Biomechanics During Functional Tasks and Unplanned Sidestep Cutting Manoeuvre
Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pooled it
- A Novel Dual-Task Paradigm for Return-to-Sport Screening After ACL Injury: A Pilot Study.Translational sports medicine · 2026Article
- Influence of Anticipation on Neuromuscular Control During a Single-Leg Diagonal Drop Jump Landing Task In Female Football Players. A Cross-Sectional Study.European journal of sport science · 2026Article
- Magnetic resonance imaging of cruciate ligament disorders: current updates.EFORT open reviews · 2025Review
- A New Way to Treat Central Nervous System Dysfunction Caused by Musculoskeletal Injuries Using Transcranial Direct Current Stimulation: A Narrative Review.Brain sciences · 2025Review
- Cortical changes associated with an anterior cruciate ligament injury may retrograde skilled kicking in football: preliminary EEG findings.Scientific reports · 2025Article
- Neurophysiology of ACL Injury.Orthopedic reviews · 2025Article
- Either Autonomy Support or Enhanced Expectancies Delivered Via Virtual-Reality Benefits Frontal-Plane Single-Leg Squatting Kinematics.Perceptual and motor skills · 2024Article
- Dependence on visual information in patients with ACL injury for multi-joint coordination during single-leg squats: a case control study.BMC sports science, medicine & rehabilitation · 2024Article
- The Evolution of Neuroimaging Technologies to Evaluate Neural Activity Related to Knee Pain and Injury Risk.Current reviews in musculoskeletal medicine · 2024Review
- Monitoring Cortical and Neuromuscular Activity: Six-month Insights into Knee Joint Position Sense Following ACL Reconstruction.International journal of sports physical therapy · 2024Article
- Neurocognitive & Ecological Motor Learning Considerations for the 11+ ACL Injury Prevention Program: A Commentary.International journal of sports physical therapy · 2024Article
- The Impact of Visual Perturbation Neuromuscular Training on Landing Mechanics and Neural Activity: A Pilot Study.International journal of sports physical therapy · 2024Article
- The Impact of Differential Knee Laxity on Brain Activation During Passive Knee Joint Loading.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2023Article
- A Preliminary Investigation into the Neural Correlates of Knee Loading during a Change of Direction Task in Individuals after Anterior Cruciate Ligament Reconstruction.International journal of sports physical therapy · 2023Article
- Article
- Brain Response to a Knee Proprioception Task Among Persons With Anterior Cruciate Ligament Reconstruction and Controls.Frontiers in human neuroscience · 2022Article
- A Multi-Systems Approach to Human Movement after ACL Reconstruction: The Nervous System.International journal of sports physical therapy · 2022Article
- Integrating neurocognitive challenges into injury prevention training: A clinical commentary.Physical therapy in sport : official journal of the Association of Chartered Physiotherapists in Sports Medicine · 2021Article
- High school female basketball athletes exhibit decreased knee-specific choice visual-motor reaction time.Scandinavian journal of medicine & science in sports · 2021Article
Corrections and comments
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Authors and funding
17 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThis study's purpose was to utilize a prospective dataset to examine differences in functional brain connectivity in male high school athletes who suffered an anterior cruciate ligament (ACL) injury relative to their non-injured peers.
methodsSixty-two male high school football players were evaluated using functional magnetic resonance imaging prior to their competitive season to evaluate resting-state functional brain connectivity. Three athletes later experienced an ACL injury and were matched to 12 teammates who did not go on to sustain an ACL injury (controls) based on school, age, height, weight, and year in school. Twenty-five knee-motor regions of interest (ROIs) were created to identify differences in connectivity between the two groups. Between-subject F and t tests were used to identify significant ROI differences using a false discovery rate correction for multiple comparisons.
resultsThere was significantly less connectivity between the left secondary somatosensory cortex and the left supplementary motor area (p = 0.025), right pre-motor cortex (p = 0.026), right supplementary motor area (p = 0.026), left primary somatosensory cortex (superior division; p = 0.026), left primary somatosensory cortex (inferior division; p = 0.026), and left primary motor cortex (p = 0.048) for the ACL-injured compared to the control subjects. No other ROI-to-ROI comparisons were significantly different between the groups (all p > 0.05).
conclusionOur preliminary data indicate a potential sensorimotor disruption for male football players who go on to experience an ACL injury. Future studies with larger sample sizes and complementary measures of neuromuscular control are needed to support these findings.
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Registered trials
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