Evidence map›Paper›PMID 31377096›Full record

ArticleBrain stimulation

Reversible neuroinhibition by focused ultrasound is mediated by a thermal mechanism.

David P Darrow, Parker O'Brien, Thomas J Richner, Theoden I Netoff, Emad S Ebbini

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain stimulation. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
63citing papers in PubMed, 2 pooled it
5.5field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

63 citing papers in PubMed, 2 syntheses or guidelines pooled it, 128 citations in OpenAlex.

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3 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

David P DarrowDepartment of Neurosurgery, University of Minnesota, MMC 96, Room D-429, 420 Delaware St SE, Minneapolis, MN, 55455, USA. Electronic address: darro015@umn.edu.
Parker O'BrienDepartment of Electrical and Computer Engineering, University of Minnesota, 7-174 Keller Hall, 200 Union Street Se. Minneapolis, MN, 55455, USA. Electronic address: obrie844@umn.edu.
Thomas J RichnerDepartment of Biomedical Engineering, University of Minnesota, 7-105 Nils Hasselmo Hall, 312 Church St. SE, Minneapolis, MN, 55455, USA. Electronic address: trichner@umn.edu.
Theoden I NetoffDepartment of Biomedical Engineering, University of Minnesota, 7-105 Nils Hasselmo Hall, 312 Church St. SE, Minneapolis, MN, 55455, USA. Electronic address: tnetoff@umn.edu.
Emad S EbbiniDepartment of Electrical and Computer Engineering, University of Minnesota, 7-174 Keller Hall, 200 Union Street Se. Minneapolis, MN, 55455, USA. Electronic address: emad@umn.edu.
University of Minnesota · US

Funding

Monitoring and Delivery of Transcranial Therapy Using Dual-mode UltrasoundR01NS098781 · NINDS · UNIVERSITY OF MINNESOTA · PI EBBINI, EMAD S. · 2016 to 2019
$1.6M
On-demand Transcranial Focused Ultrasound Neuromodulation in Awake AnimalsR21NS118785 · NINDS · UNIVERSITY OF MINNESOTA · PI EBBINI, EMAD S. · 2020 to 2020
$403k
NINDS NIH HHS R01 NS098781NINDS NIH HHS R21 NS118785
6 · The paper itself

Abstract

backgroundTranscranial focused ultrasound (tFUS) at low intensities has been reported to directly evoke responses and reversibly inhibit function in the central nervous system. While some doubt has been cast on the ability of ultrasound to directly evoke neuronal responses, spatially-restricted transcranial ultrasound has demonstrated consistent, inhibitory effects, but the underlying mechanism of reversible suppression in the central nervous system is not well understood. OBJECTIVE/HYPOTHESIS: In this study, we sought to characterize the effect of transcranial, low-intensity, focused ultrasound on the thalamus during somatosensory evoked potentials (SSEP) and investigate the mechanism by modulating the parameters of ultrasound.

methodsTFUS was applied to the ventral posterolateral nucleus of the thalamus of a rodent while electrically stimulating the tibial nerve to induce an SSEP. Thermal changes were also induced through an optical fiber that was image-guided to the same target.

resultsFocused ultrasound reversibly suppressed SSEPs in a spatially and intensity-dependent manner while remaining independent of duty cycle, peak pressure, or modulation frequency. Suppression was highly correlated and temporally consistent with in vivo temperature changes while producing no pathological changes on histology. Furthermore, stereotactically-guided delivery of thermal energy through an optical fiber produced similar thermal effects and suppression.

conclusionWe confirm that tFUS predominantly causes neuroinhibition and conclude that the most primary biophysical mechanism is the thermal effect of focused ultrasound.

Indexed as

AnimalsEvoked Potentials, SomatosensoryNeural InhibitionNeuronsRatsRats, Sprague-DawleyThalamusThermographyUltrasonic TherapyUltrasonographyFUSLow intensityNeuromodulationNoninvasiveSomatosensory evoked potentialsTranscranial focused ultrasound

Identifiers

PMID31377096
PMCPMC6851480
OpenAlexW2963986933

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.